introduction the proteome is the full complement of proteins expressed by a cell or tissue at any given time or environmental condition. proteomics is the study and identification of this set or subset of proteins (abersold & man, 2003 cristea et al., 2004). whereas the genome is composed of all the potential genes that can be expressed as proteins, the proteome is composed of all proteins actu...

Among omics, the proteomics assumes a unique role in that it offers the effectors or actuators of a biological condition. This brief review attempts to summarize the development in a relatively new but important subdiscipline of proteomics, the so-called nascent proteomics, and its potential applications in stroke research. First, we will discuss a few examples of proteomics-led discoveries in ...

The third International Conference of the Hellenic Proteomics Society, From Proteomics Research to Clinical Practice, took place in Nafplio (Greece), from 30 March to 1 April 2009. This year the conference was dedicated to the application of proteomics in clinical practice. Many scientists from different European counties participated in the conference, which made this event unique in the field...

egfr is a key molecule in cancer cells. egfr signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. we extracted proteins from astrocytoma (iii and iv) oligodendroglioma(iv) tumors and normal brain tissues and then evaluated the protein purity by bradford test and sp...

mitochondria play key roles in many cell functions including energy production, fatty acid metabolism, pyrimidine biosynthesis, calcium homeostasis, and aging. they also regulate crucial signaling cascades such as apoptosis and oxidative stress. the proteome is often used to investigate the functional correlations on protein levels. based upon the human, genome there is estimated 2000 to 2500 a...

because of the huge amounts of proteomic data and demand for new methods of laboratory analysis results, proteins collective analysis, in addition to taking less time, biostatistician assist at identification of new patterns in the data set. in this study, rat hippocampus proteome in normal and alzheimer's disease (ad) were analyzed by using proteomic techniques and bioinformatics’ analysis. pr...

The analysis of historical materials is an essential component cultural heritage conservation. Protein was one the most important and pervasive organic substances in ancient human societies. Through qualitative quantitative examination protein-based materials, it possible to clarify their source functions heritages, investigate manufacturing technology heritage, identify deterioration mechanism...

Animal production and health are of significant economic importance, particularly regarding the world food supply. veterinary sciences have evolved immensely in past six decades, genetics, nutrition, housing, management health. To address major challenges such as those posed by climate change or metabolic disorders, it is utmost importance to use state-of-the-art research tools. Proteomics othe...

Two-dimensional gel electrophoresis has been instrumental in the birth and developments of proteomics, although it is no longer the exclusive separation tool used in the field of proteomics. In this review, a historical perspective is made, starting from the days where two-dimensional gels were used and the word proteomics did not even exist. The events that have led to the birth of proteomics ...