Laboratory of Pathology — National Cancer Institute Clinical Proteomics Program, National Cancer Institute Center for Cancer Research, Bethesda, MD 20892, USA Food and Drug Administration — National Cancer Institute Clinical Proteomics Program, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD 20892, USA National Cancer Institute Biomedical Proteomics Prog...

Proteomics, the science of proteins is the global study of the expression, interaction and modification of proteins within the body. Since proteins are the intermediaries between genetic instruction and all forms of cell activity, advances in proteomics promise to provide insight into disease and to accelerate systematized discovery of new drugs. Proteomics offers medical reaseach groups a way ...

Despite the consolidation of the specialized proteomics literature around a few established journals, such as Proteomics, Molecular and Cellular Proteomics, and the Journal of Proteome Research, a lot of information is still spread in many different publications from different fields, such as analytical sciences, MS, bioinformatics, etc. The purpose of SPS' Digest is to gather a selection of pr...

The genome sequences of important model systems are available and the focus is now shifting to large-scale experiments enabled by this data. Following in the footsteps of genomics, we have functional genomics, proteomics, and even metabolomics, roughly paralleling the biological hierarchy of the transcription, translation, and production of small molecules. Proteomics is initially concerned wit...

Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples and generating large amount of data end-points. Examples of two promising proteomics technologies are mass spectrometry, including an instrument based on surface enhanced laser desorption/ionization,...

Genome sequencing of various organisms allow global analysis of gene expression, providing numerous clues on the biological function and involvement in the biological processes studied. Proteomics is a branch of molecular biology and biotechnology that has undergone considerable development in the post-genomic era. Despite the recent significant advancements in proteomics techniques, still ther...

In a global effort for scientific transparency, it has become feasible and good practice to share experimental data supporting novel findings. Consequently, the amount of publicly available MS-based proteomics data has grown substantially in recent years. With some notable exceptions, this extensive material has however largely been left untouched. The time has now come for the proteomics commu...