BACKGROUND High dose intravenous proton pump inhibitor after endoscopic therapy for peptic ulcer bleeding has been recommended as adjuvant therapy. Whether oral proton pump inhibitor can replace intravenous proton pump inhibitor in this setting is unknown. This study aims to compare the clinical efficacy of oral and intravenous proton pump inhibitor after endoscopic therapy. METHODS Patients ...

A 42-year-old woman presented with recurrent acid regurgitation and heartburn. On initial upper endoscopy, multiple mucosal breaks were seen in the lower esophagus, but no abnormalities were observed in the stomach (Fig. 1). The patient took proton pump inhibitors for consistent reflux symptoms and reflux esophagitis. On follow-up endoscopy 4 years later, confluence of mucosal breaks and stenos...

The effects of pantoprazole on xenobiotic metabolizing enzymes in rat liver microsomes were examined. Groups of female Sprague-Dawley rats were orally administered pantoprazole and other proton pump inhibitors, omeprazole and lansoprazole, at 5, 50, or 300 mg/kg/day for 7 days, followed by assays to detect changes in the levels of liver microsomal protein, cytochrome P450, cytochrome b5, NADPH ...

In their in-depth review of chronic cough and gastro-oesophageal reflux (GOR), Fontana and Pistolesi suggest that proton pump inhibitors are the most effective treatment for GOR related cough. However, most studies evaluating the efficacy of proton pump inhibitors are not placebo controlled and do not use objective markers of cough severity to assess treatment responses. We are aware of two dou...

INTRODUCTION For a few decades the long-term use of proton pump inhibitors has had wide application in the treatment of several gastrointestinal diseases. Since then, however, several studies have called attention to the possible development of anatomical and pathological changes of gastric mucosa, resulting from the long term use of this therapeutic modality. Recent experimental and clinical s...

BACKGROUND The use of proton pump inhibitors has been associated with an increased risk of hip fracture. We sought to further explore the relation between duration of exposure to proton pump inhibitors and osteoporosis-related fractures. METHODS We used administrative claims data to identify patients with a fracture of the hip, vertebra or wrist between April 1996 and March 2004. Cases were e...

In order to evaluate the utilization of variable ATP concentration produced by an oscillatory reaction (as in anaerobic glycolysis), we analyze the thermodynamic efficiency of power output of a cyclic, ATP-driven proton pump found in the plasma membrane of plant cells. The model used includes the coupling of potassium and calcium ion transport. Oscillations in the concentration of ATP can lead ...

conclusions b. oleracea demonstrated similar anti-inflammatory properties to omeprazole in rats with gerd. however, omeprazole also demonstrated genotoxic and cytotoxic effects in rats without gerd. results rats with gerd developed esophagitis and esophageal squamous cell carcinoma. b. oleracea and omeprazole-treated gerd rats presented significantly decreased inflammation in relation to non-tr...

OBJECTIVE To determine the most efficacious treatment for eradication of Helicobacter pylori with the lowest likelihood of some common adverse events among pre-recommended and newer treatment regimens. DESIGN Systematic review and network meta-analysis. DATA SOURCES Cochrane Library, PubMed, and Embase without language or date restrictions. STUDY SELECTION Full text reports of randomised ...

background : the purpose of this study was to evaluate the effect of apple cider vinegar plus ppi-based triple therapy on eradication of helicobacter pylori (h.pylori) infection. materials and methods : 116 patients with h. pylori infection were included in this randomized clinical trial. patients in control group (n=59) received amoxicillin, clarithromycin, and pantaprazole twice daily. patien...