To design new antimicrobial peptides, we have focused on various proteins which are not essential for self-defense but carry important responsibilities for biosystems. Previously, we reported that highly efficient antimicrobial properties or antiviral properties are inherent in the nuclear translocation signals and binding sites on laminin receptors. Here we introduce microtubule binding sites ...

INTRODUCTION Synaptic dysfunction and intracellular transport defects are early events in Alzheimer's disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and organelles such as brain-derived neurotrophic factor (BDNF) and mitochondria that are required for synaptic function. Meanwhile, intraneuronal accumulation of Aβ precedes its ex...

Differentiation between tumours and pseudo-tumours is essential for planning adequate treatment and for estimating outcome and future prognosis. Per definition, tumour and pseudo-tumours are lesions that look alike on ultrasound (US), computer tomography (CT) or magnetic resonance imaging (MRI) studies. Misinterpretation may lead to a significant delay of adequate treatment for malignant tumour...

Embryonic stem cells (ESC) have the ability of indefinite self-renewal and multilineage differentiation, and they carry great potential in cell-based therapies. The rhesus macaque is the most relevant preclinical model for assessing the benefit, safety, and efficacy of ESC-based transplantations in the treatment of neurodegenerative diseases. In the case of neural cell grafting, tracing both th...

A key symptom in the early stages of Alzheimer's disease (AD) is the loss of declarative memory. The anatomical substrate that supports this kind of memory involves the neural circuits of the medial temporal lobe, and in particular, of the hippocampal formation and adjacent cortex. A main feature of AD is the abnormal phosphorylation of the tau protein and the presence of tangles. The sequence ...

A pseudo-random function is a fundamental cryptographic primitive that is essential for encryp-tion, identiication and authentication. We present a new cryptographic primitive called pseudo-random synthesizer and show how to use it in order to get a parallel construction of a pseudo-random function. We show several NC 1 implementations of synthesizers based on concrete intractability assumption...

BACKGROUND The EUDAIMON study focuses on fibromyalgia syndrome (FMS), a prevalent chronic condition characterized by pain, fatigue, cognitive problems and distress. According to recent reviews and meta-analyses, Mindfulness-Based Stress Reduction (MBSR) is a promising therapeutic approach for patients with FMS. The measurement of biomarkers as part of the analysis of MBSR effects would help to ...

A pseudo-primitive word with respect to an antimorphic involution θ is a word which cannot be written as a catenation of occurrences of a strictly shorter word t and θ(t). Properties of pseudo-primitive words are investigated in this paper. These properties link pseudo-primitive words with essential notions in combinatorics on words such as primitive words, (pseudo)-palindromes, and (pseudo)-co...

PURPOSE To determine the types and frequency of ocular conditions simulating retinoblastoma (pseudo-retinoblastoma) at Farabi Eye Hospital, Tehran, Iran. METHODS We reviewed data of patients who were referred with a diagnosis of retinoblastoma to Farabi Eye Hospital oncology clinic, from January 2009 to July 2013. Examination under general anesthesia was performed for all patients. Other inve...

Pseudo-random sequences are essential ingredients of every modern digital communication system including cellular telephones, GPS, secure internet transactions, and satellite imagery. Each application requires pseudo-random sequences with specific statistical properties. This book describes the design, mathematical analysis, and implementation of pseudo-random sequences, particularly those gene...