BACKGROUND Failure in the treatment of burn patients infected with Pseudomonas aeruginosa could happen as a result of the acquisition of antibiotic resistance, including carbapenems. OBJECTIVES The aim of the present study was to investigate the phenotypic and genotypic characteristics of the Pseudomonas aeruginosa strains, isolated from burn patients. PATIENTS AND METHODS During a 12 month...

background and objectives: bacterial resistance to conventional antibiotics has become a widespread public health prob- lem. the aim of this study was to investigate the influence of zinc oxide nanoparticles (zno nps) on the antibacterial activity of several conventional antibiotics against pseudomonas aeruginosa. materials and methods: zno nps were prepared by solvothermal method and dispersed...

background and objectives : the main cause of serious nosocomial infections is a gram-negative pathogen known as pseudomonas aeruginosa (p. aeruginosa). carbapenems are widely used as an appropriate treatment for these infections, however resistance to these agents has been observed and is increasing. metallo beta-lactamase (mbls) enzyme is one of the main causes of resistance to carbapenem. in...

background : lactobacilli are the well known friendly bacteria for their probiotic activities against pathogens. the inhibitory activity of different strains of lactobacilli either obtained as commercial products or isolated from human feces was investigated against the clinical isolates of pseudomonas aeruginosa. the isolates were selected as the most resistant strains when challenged with ant...

conclusions biofilm formation (both strong and weak) strongly correlated with psla gene carriage. biofilm formation also correlated with mbl and ampc β-lactamase production. more importantly, multiple-β-lactamase phenotype was associated with formation of strong biofilms. results biofilm formation was observed in 43.5% of the isolates, of which 66.7% produced strong and 33.3% formed weak biofil...

background: sigma factors are proteins that regulate transcription in bacteria. sigma factors can be activated in response to different environmental conditions. the rpos (rna polymerase, sigma s) gene encodes sigma-38 (σ38, or rpos), a 37.8 kda protein in pseudomonas aeruginosa (p. aeruginosa) strains. rpos is a central regulator of the general stress response and operates in both retroactive ...

objective(s): bacterial biofilm formation causes many persistent and chronic infections. the matrix protects biofilm bacteria from exposure to innate immune defenses and antibiotic treatments. the purpose of this study was to evaluate the biofilm formation of clinical isolates of pseudomonas aeruginosa and the activity of zinc oxide nanoparticles (zno nps) on biofilm. materials and methods: aft...

background : bacterial infections in burn and wound patients are common and difficult to control. the aim of the current study was to evaluate the ability of full length oprf to elicit the production of protective igg in mice burn wound sepsis model against p. aeruginosa infection. methods : oprf protein was expressed and purified by ni-nta. the purified protein as used to immunize balb/c mice....

pseudomonas aeruginosa as an opportunistic pathogen is a significant cause of acute and chronic infections in patients with compromised defenses. this bacterium is motile via a single polar flagellum made of polymerized flagellin subunits differentiated into two major serotypes: a and b. flagellin plays an important role as a virulence factor in the adhesion, colonization and invasion of p. aer...

objective: pseudomonas aeruginosa is the major cause of septicemia and wound infection in burned patients. immunotraphy is the best practical way for prevention and treatment of these infections. flagella as one of the most important bacterial virulence factors has important role in attachment, motility, chemotaxis and tlr-5-dependent immune response so that it propounded as a vaccine candidate...