BACKGROUND Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet, exhibits anticonvulsant properties that may contribute to the seizure protection conferred by the diet. The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role. METHODS Acetone and its major metabolites-acetol, 1,2-p...

The lung provides a portal of entry that could be used to rapidly deliver anticonvulsant substances to the brain to treat seizures. In the present study, we demonstrate that midazolam, a water-soluble anticonvulsant benzodiazepine, confers potent seizure protection when administered via the intrapulmonary route. High dose (100 mg/kg) intraperitoneal midazolam induced loss-of-righting reflex in ...

objective: previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for rosa damascena (r. damascena). in the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of r. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (ptz). materials and methods: the rats were divided to five groups: (1) control...

OBJECTIVES Phthalimide-based derivatives have anticonvulsant activity like as phenytoin by inhibition of sodium channel. In our previously research we mentioned about some phthalimide derivatives as potent anticonvulsant agents. MATERIALS AND METHODS Fourteen analogs of 2-substituted phthalimide pharmacophore were synthesized and then were evaluated for the anticonvulsant activities in pentyl...

Introduction: Flunixin Meglumine (FM) is a nonsteroidal antiinflammatory drug (NSAID) and nonselective cyclooxygenase (COX) inhibitor. Since it has been suggested that COX enzyme plays a role in seizure, this research is performed to assess the therapeutic effects that this compound might have in seizures induced by PTZ. Methods: In this research, male wistar rats (200 ± 20 g) were given int...

Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. Several DGK isoforms have been implicated in the pathogenesis of seizure, but the role of DGKβ in seizure is unknown. In the present study, we investigated the involvement of DGKβ in seizure using DGKβ knockout (KO) mice. Seizures were more severe in DGKβ KO mice than in wild-type (WT) mice after pentyle...

Sarcosine, a natural amino acid found in muscles and other body tissues, is an endogenous glycine transporter type 1 inhibitor that increases the glycine concentration, resulting in an indirect potentiation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Sarcosine, similar to other NMDA receptor-activating agents, is an effective adjuvant in the treatment of schizophrenia. It...

introduction: ketoprofen is an nsaid and selective cox-1 inhibitor. in our previous study the role of flunixin meglumine, a nonselective cox inhibitor was studied on seizure and its anticonvulsant effects were confirmed. therefore this research is performed to assess the role of a selective cox-1 inhibitor, ketoprofen in treatment of seizures induced by ptz. methods: in this research, male wist...

objective: at present, there are many antiepileptic drugs with a wide range of side effects on the human body. it was assumed that zataria multiflora boiss (z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. the aim of the present study was to elucidate the effect of z. multiflora hydroalcoholic extract and its fraction ext...

Eighteen new 5-benzylidene-3-(4-arylpiperazin-1-ylmethyl)-2-thioxo-imidazolidin-4-ones were designed as hybrid structures from previously reported anticonvulsant compounds, synthesized and tested for anticonvulsant activity. Initial anticonvulsant screening was performed using the strychnine (2 mg/kg IP) potent generalized-induced seizure and pentylenetetrazole (PTZ) (60 mg/kg IP) acute clonic-...