Background and Objective: Chronic arsenic toxicity is a widespread problem; the role of brain oxidative stress has been suggested in the genesis of epilepsy and in the post-seizure neuronal death. However, studies investigating the effects of arsenic on seizure and related mechanisms are limited. The purpose of this study was to examine the effect of prolonged exposure to sodium arsenite on oxi...

Epilepsy is a chronic neurological disorder characterized by recurrent seizures. However, approximately one-third of epilepsy patients still suffer from uncontrolled seizures. Effective treatments for epilepsy are yet to be developed. N (6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside (B2) is a N(6)-substitued adenosine analog. Here we describe an investigation of the effects and mechanisms of...

PURPOSE 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment with 2-DG can promote seizure susceptibility by assessing its effects on seizure threshold. For compar...

introduction: olive leaf contains anti-inflammatory and cox-2 inhibitor compounds. considering the role of the cox enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by ptz. methods: in this research, male wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 μl saline or olive leaf extract (125 μg, 250 μg and ...

OBJECTIVE Cathodal transcranial direct current stimulation (tDCS) is a focal neuromodulation technique that suppresses cortical excitability by low-amplitude constant electrical current, and may have an antiepileptic effect. Yet, tDCS has not been tested in status epilepticus (SE). Furthermore, a combined tDCS and pharmacotherapy antiseizure approach is unexplored. We therefore examined in the ...

Epilepsy as well as chronic use of most antiepileptic drugs, particularly in children, predisposes to cognitive impairment. The brain is considered abnormally sensitive to oxidative stress and damage which observed during seizure activity. Omega-3 (OM3) fatty acids are known antioxidants that play a role in nervous system activity, cognitive development, memory-related learning, and synaptic tr...

Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure. Moreover, we studied the hypnotic effect and locomotor activity of quinine...

regarding the therapeutic properties of nigella sativa (ns), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (ptz) - induced repeated seizures.there were 4 experimental groups including: 1- control group; received saline, 2- ptz group ; received saline and ptz (50 mg/kg, i.p) , 3-ptz- ns 200 and 4...

Brain-derived neurotrophic factor (BDNF) and c-Fos are shown to promote epileptogenesis and are taken as a marker of neuronal activity. The present study investigated the expression of BDNF and c-Fos in mice brain with pentylenetetrazol- (PTZ-) induced generalized seizure and evaluated the effect of novel tryptamine derivative HHL-6 on the expression of these two markers. The subconvulsive dose...