Isradipine belong to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is used in the treatment hypertension, angina pectoris, addition Parkinson disease. goes under BCS II drug (low solubility-high permeability). The will experience extensive first-pass metabolism liver, therefore, oral bio-availability be approximately15 24 %.
 
 aim this study was formulate and opt...

Abstract Background Nanocrystals of any drug are pure solid particles with a mean diameter in nanometer range. Dissolution is crucial factor for absorption medicine case water-insoluble or poorly soluble drugs. The aim this study was to develop nanocrystals hydrophobic drug, Lercanidipine, by addition solvent an antisolvent high-speed homogenization achieve dissolution and solubility enhancemen...

Many sensors have to be used simultaneously for multipoint carbon dioxide (CO(2)) observation. All the sensors should be calibrated in advance, but this is a time-consuming process. To seek a simplified calibration method, we used four commercial CO(2) sensor models and characterized their output tendencies against ambient temperature and length of use, in addition to offset characteristics. We...

BACKGROUND Photoselective vaporization (PVP) with the GreenLight HPS 120-W laser (GLL) was recently introduced for treatment of benign prostatic hyperplasia (BPH). OBJECTIVE To compare results of GLL PVP and transurethral resection of the prostate (TURP) for treatment of BPH. DESIGN, SETTING, AND PARTICIPANTS A total of 120 patients with BPH were randomly assigned to two equal groups: TURP ...

The genetic determinants for the aerobactin iron uptake system of plasmid ColV-K30, cloned as recombinant plasmid pABN1, were mapped by insertional inactivation using Tn1000 (gamma delta). Sites of insertion resulting in loss of aerobactin biosynthesis spanned ca. 5.5 kilobase pairs of cloned ColV-K30 DNA contiguous with a 2-kilobase-pair region in which transposon insertion resulted in loss of...

OBJECTIVE To assess the long term cognitive outcome of unilateral posteroventral pallidotomy (PVP) and the overall efficacy of the surgery. METHODS Forty two (29 left and 13 right PVP) patients with Parkinson's disease underwent neurological and neuropsychological testing before PVP and at 3 and 12 months after PVP. The neuropsychological testing battery emphasised measures of verbal learning...

Freeze-substitution was performed on strains of Escherichia coli, Pasteurella multocida, Campylobacter fetus, Vibrio cholerae, Pseudomonas aeruginosa, Pseudomonas putida, Aeromonas salmonicida, Proteus mirabilis, Haemophilus pleuropneumoniae, Caulobacter crescentus, and Leptothrix discophora with a substitution medium composed of 2% osmium tetroxide and 2% uranyl acetate in anhydrous acetone. A...

Poly(vinyl pyrrolidone) (PVP) was grafted onto Pluronic F127 (PEO-PPO-PEO) to produce novel amphiphilic PVP-g-F127 graft copolymers. A controlled synthesis method was used to graft PVP onto different parts of F127. Two types of graft polymers were obtained: one has PVP grafted onto the PEO part of F127 and the other has PVP grafted onto the PPO part of F127. The association behavior of the two ...

We propose a method for the synthesis of a colloidal ZnO solution with poly(N-vinylpyrrolidone) (PVP) as stabilizer. Stable colloidal solutions with good luminescence properties are obtained by using PVP as stabilizer in the synthesis of ZnO nanoparticles by a sol-gel method assisted by ultrasound. Nanoparticles with sizes of 30-40 nm in a PVP matrix are produced as a solid product. The colloid...

The objective of this paper is to evaluate the effect of Plant Variety Protection (PVP) on the productive merit ⁄yield increases of US seed varieties. As an example, we use wheat varieties, which are and have been available as both protected and unprotected under PVP from both the public and private sectors. We find evidence that PVP has contributed to the genetic improvement of wheat, using va...