BACKGROUND Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome (OMIM 604416) is a rare autosomal dominant inherited autoinflammatory syndrome characterized by pyogenic sterile arthritis and less frequently accompanied by pyoderma gangrenosum and acne. It is associated with dominant missense mutations in the proline-serine-threonine phosphatase-interacting protein 1 gene (...

Characterization of proteolytic enzymes and their substrates presents a formidable challenge in the context of biological systems. Despite the fact that an estimated 2% of the human genome codes for proteases, only a small fraction of these enzymes have well-characterized functions. Much of the difficulty in understanding protease biology is a direct result of the complexity of regulation, loca...

http://bmj.com/cgi/content/full/333/7560/181 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/333/7560/181#BIBL This article cites 24 articles, 6 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/333/7560/181 You can respond to this article at: http://bmj.com/cgi/content/full/333/7560/181#responses free...

Recurrent pyogenic cholangitis is prevalent in Hong Kong and East Asia. While the recent influx of Asian immigrants has resulted in more cases appearing in the West, over the past three decades, the overall incidence in East Asia has been in decline. The experience of the Queen Mary Hospital and other hospitals in the region has been confirmed by comprehensive surveys. The decline in incidence ...

Casadio, R., Baccarini Melandri, A. & Melandri, B. A. (1975) in Electron Transfer Chains and Oxidative Phosphorylation (Quagliriello, E., Papa, S . , Palmieri, F., Slater, E. C. & Siliprandi, N., eds.), pp. 407-410, North-Holland, Amsterdam Jackson, J. B. & Crofts, A. R. (1969) FEBS Lett. 4, 185-189 Leiser, M. & Gromet-Elhanan, Z . (1974) FEBSLett. 43, 267-270 Melandri, B. A., Baccarini Melandr...

We herein report a severe case of pyoderma gangrenosum occurring in a burn patient and discuss the possibility of occult complications of this pathological state in daily treatment.

Romina Papa Ezdra, Inés Bado, Nicolás Cordeiro, Claudia Gutierrez, Patricia Hitateguy, Verónica Seija, Rafael Vignoli Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Departamento de Laboratorio Clínico, Área Microbiología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, ...