BACKGROUND The objective of our study was to assess the cost-effectiveness of ivabradine plus standard care (SoC) in chronic heart failure (CHF) patients with sinus rhythm and a baseline heart rate ≥ 75 b.p.m. in Greece, in comparison with current SoC alone. METHODS An existing cost-effectiveness model consisting of two health states, was adapted to the Greek health care setting. All clinical...

Following some years of practical application, weaknesses have been identified in the original 2018 version ‘social footprint’ methodology, where wellbeing was seen as exclusively related to consumption activities and inseparably linked production through budget constraint, implying that value limited be a mirror production. Several improvements both methodology data are presented here. The the...

The concept of the quality-adjusted life year (QALY) provides a simple technical tool for summarising the impact a medical condition has on someone's life and the impact a health care intervention can have on that medical condition. In the former case, QALYs (and related concepts, such as disability-adjusted life years, DALYs) have been useful in producing summary statistics on the burden of di...

Kilbridge correctly points out that comparative effectiveness research (CER) does not require cost data. It should also be pointed out, however, that the composition of the quality-adjusted life-year (QALY) gain of one intervention over another—whether the QALY gain is achieved mainly in the dimension of longevity or in the dimension of quality of life—has real consequences in terms of comparat...

BACKGROUND AND PURPOSE Recent atrial fibrillation guidelines recommend the incorporation of patient preferences into the selection of antithrombotic therapy. However, no trial has examined how incorporating such preferences would affect quality-adjusted survival or medical expenditure. We compared 10-year projections of quality-adjusted survival and medical expenditure associated with two atria...

Before updating any willingness-to-pay (WTP) per quality-adjusted life-year (QALY) threshold, a few points must be recognized. Ethical justification for using WTP thresholds and QALYs lies in incorporating the preferences of those whose treatment could affected by resulting resource allocations. For thresholds, such depends on sufficiency match between group-members an insurance pool from which...

AIMS To estimate the long term cost effectiveness of treatment for amblyopia in 3 year old children. METHODS A cost utility analysis was performed using decision analysis including a Markov state transition model. Incremental costs and effects during the children's remaining lifetime were estimated. The model took into account the costs and success rate of treatment as well as effects of unil...

Aims: To estimate the long term cost effectiveness of treatment for amblyopia in 3 year old children. Methods: A cost utility analysis was performed using decision analysis including a Markov state transition model. Incremental costs and effects during the children’s remaining lifetime were estimated. The model took into account the costs and success rate of treatment as well as effects of unil...

The cost-effectiveness of hormone replacement therapy (HRT) based on a societal perspective is reassessed based on new medical evidence found in the Women’s Health Initiative (WHI). Within a model framework using an individual state transition model the cost-effectiveness of 50-60 year old women with menopausal symptoms is assessed in Sweden. The Markov model has a 50 year time horizon divided ...

PURPOSE To evaluate the cost-effectiveness of interferon alfa (IFN alpha) treatment of patients with chronic myelogenous leukemia relative to conventional chemotherapy. MATERIALS AND METHODS A decision-analysis model that involved a multistate Markov process was designed to estimate the expected cost and quality-adjusted life expectancies for two cohorts of patients to be administered convent...