In this study 90 individuals of recombinant inbred lines (RILs) were developed by crossing subspecies of japonica rice cultivar, ‘Nagdong’ and an indica type cultivar, ‘Cheongcheong’. These individuals were used to identify the quantitative trait loci of panicle traits using SSR markers. A genetic linkage map was constructed using one hundred fifty four simple sequence repeat ...

Although the interval mapping method is widely used for mapping quantitative trait loci (QTLs), it is not very well suited for mapping multiple QTLs. Here, we present the results of a computer simulation to study the application of exact and approximate models for multiple QTLs. In particular, we focus on an automatic two-stage procedure in which in the first stage “important” markers are selec...

With the increasing number of polymorphic markers identified on the genetic map, positional cloning has become an extremely powerful tool, permitting the linkage and identification of a large number of disease genes. As the human genome project pro­ gresses and the gene map becomes as dense as the microsatellite polymorphism map, scientists will identify more disease genes through a combination...

Some diseases, such as cystic fibrosis and Huntington’s disease, are the result of a change in a single gene. No single gene is responsible for alcohol abuse and dependence, however. Many genes that play roles in a variety of normal human behaviors and sensory perception are involved. Research has not yet pinpointed specific genes that “predispose” a person to alcohol abuse or dependence. Once ...

Recent studies with the fruitfly Drosophila suggest that alleles of loci known from classical genetics can make major contributions to continuous-trait variation.

Khoury et al. (Am J Hum Genet 1988;42:89-95 and Am J Epidemiol 1993;137:1241-50) presented an epidemiologic approach to examine genotype-environment interaction in situations where the disease is either present or absent. In this article, the author extends the approach of Khoury et al. to quantitative outcome variables. This extension is relevant for diseases that are extremes on a continuum o...