In this research article, a new chromatographic method ultra-performance liquid chromatography (UPLC) was developed for the quantification of ivermectin (IMT)-preziquantel (PRZQ) in two-component mixture and veterinary dosage form mixture. The separation studied drugs (IMT PRZQ) carried out on Waters Acquity ® BEH C18 column (50mm x 2.1 mm i.d., 1.7 m) using mobile phase consisting water-aceton...

It is common to treat some diseases with more than one medication simultaneously. Since more than one neurotransmitter system is involved in alcohol-seeking behaviour, then a therapeutic approach that targets more than one system should be more effective in reducing alcohol intake than one addressing a single system. To test this hypothesis, we compared the efficacy of low doses of individual d...

background : drug abuse is one of the important challenges in the field of mental health and adolescence health promotion. because of the social and medical cost of drug abuse and its consequences among youth people, it is necessary to intervene effectively. this theoretical based study explained predictability of the theory of planned behaviour (tpb) on drug abuse related behaviours. methods :...

one of the common methods to cure unsaturated polyester resins is to use dual initiators. in order to produce an appropriate composite, it is necessary to know the effect of dual initiators on curing behavior. in this paper the effect of benzoyl peroxide, bpo, and tertiary butyl perbenzoate, tbpb, and their mixtures on thermal curing of an unsaturated polyester resin have been investigated. bpo...

Synthesis of quaternary quantum circuits involves basic quaternary gates and logic operations in the quaternary quantum domain. In this paper, we propose new projection operations and quaternary logic gates for synthesizing quaternary logic functions. We also demonstrate the realization of the proposed gates using basic quantum quaternary operations. We then employ our synthesis method to desig...

Introduction and objective: Cryptosporidium parvum is a protozoan parasite that is a common cause of diarrhea in both animals and humans worldwide. There is no effective specific chemotherapeutic treatment. The aim of this study was to survey and compare the anticryptosporidial effect of two anticoccidial drugs, Monensin, Toltrazuril and synergic effect on oocysts of C. parvum in vitro. Materia...

Although the qac genes are named after one of their main substrates (i.e., quaternary ammonium compounds), these genes also code for resistance to a broad spectrum of other cationic compounds such as intercalating dyes, diamidines and biguanides. The various Qac proteins are involved in relatively low specific effluxbased multidrug pumps and belong to a family of small multidrug resistance prot...

To reduce the environmental impacts and costs of production biolubricant, this work proposes use vegetable oil mixtures that have not been chemically modified. Formulations biolubricants were proposed with jatropha curcas, castor, macauba kernel, pulp oils since these potential physical-chemical properties to generate a high-performance biolubricant. A simplex centroid quaternary mixture design...

Cytosolic sulfotransferases (SULTs) are responsible for the metabolism of a variety of drugs, xenobiotics, and endogenous compounds. Most cytosolic SULTs are found to be homodimers. However, transformation between monomeric and dimeric SULTs can be achieved by a single amino acid mutation. The importance of quaternary structure for cytosolic sulfotransferase was investigated using recombinant h...