Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer treatment. This conference was the first of its kind to bring together a wide range of clinicians, researchers, and industry professionals to address the potential causes, preventions, and treatments for this drug toxicity. Intraepidermal nerve fiber loss, axonal degeneration, immune cell infiltration, a...

Cardiovascular diseases are the leading causes of mortality and morbidity in Brazil. The primary and secondary preventions of those diseases are a priority for the health system and require multiple approaches to increase their effectiveness. Biomarkers are tools used to more accurately identify high-risk individuals, to speed the diagnosis, and to aid in treatment and prognosis determination. ...

Most Parkinson's disease (PD) patients present without known family history and without a diagnosed prodromal phase, underscoring the difficulty of employing primary (neuroprevention) and secondary (neuroprotection) preventions. In cases of monogenic forms, however, potential gene-carrying family members of a proband could engage in neuroprevention, such as exercise or diet modifications, to at...

Precision medicine research efforts both in basic science discovery and clinical implementation are well underway and promise to provide individualized preventions and treatments, improving overall health care delivery. To achieve these goals, advances in data capture and analysis are needed spanning different types of 'omic and clinical data. The efforts to enhance precise treatments for all m...

Metabolic syndrome is becoming commoner due to a rise in obesity rates among adults. Generally speaking, a person with metabolic syndrome is twice as likely to develop cardiovascular disease and five times as likely to develop diabetes as someone without metabolic syndrome. Increasing oxidative stress in metabolic syndrome and Parkinson's disease is mentioned in the comprehensive articles; howe...

Le livre Vietnamese Organized Crime in the Czech Republic (Le crime organise des Vietnamiens en Republique tcheque), paru 2020 aux editions Palgrave MacMillan, s’inscrit dans la collection Preventions And Security Management. Cette serie propose analyses scientifiques relatives a criminalite et gestion de l’ordre public. volume consacre reseaux organisations criminelles vietnamiennes tcheque pr...

The Quaternary has been described as an important time for genetic diversification and speciation. This is based on the premise that Quaternary climatic conditions fostered the isolation of populations and, in some instances, allopatric speciation. However, the 'Quaternary Ice-Age speciation model' rests on two key assumptions: (i) that biotic responses to climate change during the Quaternary w...

With the continuous development of oilfield, number oil and water wells is increasing, casing loss on rise. This paper analyzes researches to further understand causes loss, proposes measures protect in western part area A. It summarizes experience methods “six checks, six preventions controls” for protection, which provides direction preventing a basis reasonable development.

An in situ IR technique was applied in the selective synthesis of the key intermediate for rapamycin derivatives, which made the reaction endpoint easily defined. This technology solved a bothersome problem in the preparation of rapamycin derivatives, and based on this technique, the 31-OH and 42-OH of rapamycin were chemically modified by a series of quaternary ammonium salts to generate 11 co...

In this paper, a new construction of quaternary bent functions from quaternary quadratic forms over Galois rings of characteristic 4 is proposed. Based on this construction, several new classes of quaternary bent functions are obtained, and as a consequence, several new classes of quadratic binary bent and semi-bent functions in polynomial forms are derived. This work generalizes the recent wor...