WILKINS, A.L., MILES, C.O., DE KOCK, W.T., ERASMUS, G.L., BASSON, A.T. & KELLERMAN, T.S. 1996. Photosensitivity in South Africa. IX. Structure elucidation of a ~-glucosidase-treated saponin from Tribulus terrestris and the identification of saponin chemotypes of South African T. terrestris. Onderstepoort Journal of Veterinary Research, 63:327-334 Saponin C, a ~-glucosidase-treated saponin isola...

Four new saponins, 3-O-[beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranosyl]-16a lpha-hydroxyoleanolic acid 28-O-beta-D-glucopyranosyl ester (called aralia-saponin I), 3-O-[beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranosyl]-16a lpha-hydroxyhederagenin 28-O-beta-D-glucopyranosyl ester (aralia-saponin II), 3-O-[beta-D-glucopyranosyl(1-->3)-beta-D-glucopyranosyl(1-->3)-alpha-L-+ ++arabinopyr...

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

Saponins can be classified as triterpenoid (C30) or steroidal (C27), based on their carbon nucleus (aglycone). Sugar residues are linked to the aglycone, conferring an amphiphilic nature on these molecules, which is relevant for their biological activities. Saponins include a large variety of molecules that find several applications in pharmacology. Saponins have been shown to display immunoadj...

acanthophyllum laxiusculum is one of the most widely distributed species of the genus in iran that flourishes in steppe and mountainous regions of the country. in the present study, water-soluble content of a. laxiusculum roots was extracted by boiling water and further successively purified partially by a defined solvent system. surface tension measurements revealed the ability of plant extrac...

Brachiaria species are cultivated worldwide in tropical and subtropical climates as the main forage source for ruminants. Numerous tropical and warm-season grasses cause hepatogenous photosensitization, among them several species of Brachiaria. Steroidal saponins present in these plants may be responsible for liver damage. However, sporidesmin and other hepatotoxic mycotoxins are likely to prod...

Jiaogulan (Gynostemma pentaphyllum; GP) contained a saponin glycoside which was related to ginseng saponin. The purpose of this study was to identify the main saponin in water extract GP compared to methanol and ethanol extract. The sample was prepared by alkaline cleavage, trimethylsilyl (TMS) derivatization and gas chromatographic-mass spectrometric (GC-MS) analysis comparison with standard g...

Two natural saponins 1 and 2, isolated from Solanum indicum L., and containing 2,3-branched sugar moieties, have been efficiently synthesized. Partially protected monosaccharide and disaccharide donors were used to facilitate target synthesis. Stereo factors were critical in incorporating 2,3-branched sugars on steroid aglycones. Saponin 1 was synthesized in five steps and 30% overall yield, wh...

In a previous study by Omura and Osogoe (1951), it has been shown that in acute saponin poisoning in rabbits, injury to sinusoidal walls opens the bone marrow parenchyma to the blood current and the marrow cells are depleted to a large extent. Since the mode of reaction of the reticuloendothelial (RE) cells lining the sinusoidal walls in the bone marrow and liver to saponin is still unknown, th...

Background: Saponins identified from fenugreek (Trigonella foenum-graecum) seeds are reported effective on dyslipidemia. However, the definite mechanism is still not elucidated systematically. In this study, we evaluate the effects of saponin extract on cholesterol absorption, metabolism, synthesis, and reverse cholesterol transport in vivo.Methods: Saponin extract was prepared according to a c...