introduction: the radioimmunoscintigraphy (ris) has found widespread clinical applications in  tumor  diagnosis.  human  epithelial  mucin,  muc1,  is  commonly  over  expressed  in  adenocarcinoma including 80% of breast cancers and represents a useful target for ris. the pr81  is  a  new  murine  anti-muc1  monoclonal  antibody  that  was  found  to  react  with  the  membrane  extracts of se...

Owing to their large size proteinaceous drugs offer higher operative information content compared to the small molecules that correspond to the traditional understanding of druglikeness. As a consequence these drugs allow developing patient-specific therapies that provide the means to go beyond the possibilities of current drug therapy. However, the efficacy of these strategies, in particular "...

The imidazoquinoline and imidazoquinoxaline food mutagens found in cooked meat are being synthesized by unambiguous methods that allow for the preparation of sufficient quantities of material for biological studies. These methods avoid difficult separations of regioisomeric mixtures of products and are designed to allow incorporation of specific high level tritium labeling.

OBJECTIVE The authors have conjugated chelating agents (DOTA and NODAGA) with a peptide (pituitary adenylate cyclase-activating peptide [PACAP] analogue) that has a high affinity for VPAC1 receptors expressed on cancer cells. To determine a suitable chelating agent for labeling with (68)Ga, they have compared the labeling kinetics and stability of these peptide conjugates. METHODS For labelin...

Positron Emission Tomography (PET) is a nuclear medicine imaging technique that is widely used in early detection and treatment follow up of many diseases, including cancer. This modality requires positron-emitting isotope labeled biomolecules, which are synthesized prior to perform imaging studies. Fluorine-18 is one of the several isotopes of fluorine that is routinely used in radiolabeling o...

Recent progress in radiolabeling of macro- and middle-sized molecular probes has been extending possibilities to use PET imaging for dynamic application drug development therapeutic evaluation. Theranostics concept also accelerated the sharpening contrast proper target recognition even cellular types/subtypes selection patients who should be treated by same molecules recognition. Here, brief su...

introduction:targeted radionuclide therapy (trt) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. trt is generally performed with a single radionuclide. in this study we investigated the feasibility of combined trt with a high-energy beta emitter (153sm) and a low energy beta emitter (177lu) in wistar rats. methods: the cocktail complex of...