After practicing medicine for two years, he entered graduate school and in May 2005 received his Ph.D. in Biochemistry and Molecular Genetics at the University of Alabama at Birmingham. He is currently a research associate at the University of Wisconsin-Madison. He is the recipient of the American Medical Association's Physican's Recognition Award and was also recipient of the Outstanding Gradu...

INTRODUCTION Approximately 10 - 20% of prostate cancer cases ultimately progress to castration-resistant prostate cancer (CRPC), for which there is a poor prognosis and a therapeutic need. Radium-223 dichloride (radium-223 [Xofigo]) is a first-in-class α-emitting radiopharmaceutical shown to significantly prolong overall survival in patients with CRPC with symptomatic bone metastases and no vis...

INTRODUCTION Bone seeking radiopharmaceuticals have been used for decades in the palliation of pain from bone metastases emerging from prostate cancer. Recent clinical evidence has demonstrated an improved survival in men with metastatic castration resistant prostate cancer (CRPC) with radium 223. MATERIAL AND METHODS A review of the literature was performed to identify the role of radiopharm...

We used two short-lived radium isotopes (223Ra, 224Ra) and a mass balance approach applied to the radium activities to determine the nutrient contribution of saline submarine groundwater discharge to the coastal waters of the northern Gulf of Aqaba (Israel). Radium isotope activities were measured along transects during two seasons at a site that lacked any obvious surficial water input. An ons...

Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer. Different radionuclides that emit β-rays such as (153)Samarium and (89)Strontium and achieve palliation are commercially available. In contrast to β-emitters, (223)Radium as a α-emitter has a short path-length. The advantage of the α-emitter is thus a highly loca...

Background: Radon is an odourless, colourless and tasteless gas and it is the first cause of lung cancer among non- smokers. The assessment of the level of radium in building materials helps in understanding the radiological implications. It has been observed that everyone has some levels of exposure to them. Therefore measurement of radium and radon in the soil samples are important f...

The insertion into an animal tumor of buried capillary glass tubes containing radium emanation presents a comparatively new departure in radium therapy and is undoubtedly destined to play a prominent part in the future development of the whole field of radiotherapeutics. The technique employed on animals and human beings is as follows: Radium emanation, the first active product of decomposition...

The radium atom is a promising system for studying parity and time invariance violating weak interactions. However, available experimental spectroscopic data for radium is insufficient for designing an optimal experimental setup. We calculate the energy levels and transition amplitudes for radium states of significant interest. Forty states corresponding to all possible configurations consistin...

This little book gives a short account of cases treated by the author with radium in the hope that it may draw the attention of the general practitioner and student to the conditions in which this valuable therapeutic agent may be of use. The first portion of the work is devoted to a short summary of the physical problems connected with radium, including apparatus, screening, methods of applica...

The largest fraction of the natural radiation exposure we receive comes from a radioactive gas, radon and its decay products (nearly 50%). The radon gas can enter to the body via respiring, drinking and eating and caused damage to respiratory and digestion systems. Also radium-226 is widely distributed in the environment. When a person ingests radium, this element deposits in bones and cause to...