This is a case of follicular thyroid carcinoma with extensive lung, bone and brain metastases. Multi-modality treatments including total thyroidectomy, modified radical neck dissection, cranial radiotherapy and Iodine-131 (RAI) therapy were instituted. Post RAI therapy planar whole body scan showed RAI avid metastases in the skull, cervical spine, bilateral lungs and abdomen. With the use of SP...

Dr. P. D. Bose, M.B.; Lt.-Col. R. Bird* C.I.E., M.D., F.R.C.S., M.V.O., M.S., I.M.S.; Lt.-Col. R. P. Wilson, F.R.C.S., D.P.H., I.M.S.; Major N. P. Sinha, I.M.S.; Dr. Bepin Behari Ghose, M.B.; The Hon'ble Dr. Nil Ratan Sircar, M.A., M.D.; Dr. S. P. Sarbadliikary, c.l.E., M.b. ; Rai Satis Chandra Banerjee Bahadur, L M.S.; Rai U. N. Bralimaehari Bahadur, M.A., M.D., Ph.D.; Rai Haridhan Dutt Bahadu...

AIMS We compared the effects of total thyroidectomy (TTx) and radioiodine (RAI) administration on the course of thyroid hormones and thyroid-stimulating immunoglobulins (TSI) in patients with Graves' disease. METHODS We retrospectively studied 80 patients initially treated with antithyroid drugs and requiring either RAI (8.3 ± 1.7 mCi of (131)I; n = 40) or TTx (n = 40) as second-line therapy....

UNLABELLED Therapeutic options for toxic thyroid nodules (TTNs) are surgery, radioiodine (RAI), and percutaneous ethanol injection (PEI). Surgery is generally considered for TTNs larger than 4 cm. However, some patients may be at high surgical risk. The purpose of the study was to evaluate the efficacy of 2 nonsurgical modalities for these TTNs. METHODS Twenty-two patients with TTNs larger th...

The anterior insula (AI) plays a key role in affective processing, and insular dysfunction has been noted in several clinical conditions. Real-time functional MRI neurofeedback (rtfMRI-NF) provides a means of helping people learn to self-regulate activation in this brain region. Using the Blood Oxygenated Level Dependant (BOLD) signal from the right AI (RAI) as neurofeedback, we trained partici...

The aim of this study was to assess in vitro the surface roughness (Ra) of human enamel exposed or not exposed to the action of a bleaching agent containing 10% carbamide peroxide (CP) after brushing with different dentifrices. Ninety-six human enamel specimens were divided into 2 groups: GI--exposed to the action of 10% CP; GII--not exposed. These were subdivided into 4 brushing subgroups: (CE...

BACKGROUND Indications for performing a prophylactic central neck dissection (pCND) in papillary thyroid cancer (PTC) remain controversial. It is unclear how identification of lymph node (LN) metastases should impact the decision to treat with radioactive iodine (RAI). The goals of this study were to identify indications for performing pCND and identify factors that predict the use of adjuvant ...

INTRODUCTION Patients with type 2 diabetes mellitus (T2DM) often require intensification of basal insulin therapy. This retrospective, observational study compared real-world outcomes in US patients with T2DM treated with insulin glargine who added a rapid-acting insulin (RAI) (basal-bolus approach) with those who switched to premixed insulin (PMX). METHODS The national US IMPACT® database wa...

BACKGROUND Graves' disease is an autoimmune disorder with the presence of TSH receptor autoantibodies (TRAb). TRAb are produced mainly by lymphocytes infiltrating the thyroid gland. The aim of this study was to investigate the influence of the reduction of thyroid volume (TV) on TRAb level after radioiodine (RAI) administration in a group of patients with Graves' disease. MATERIAL AND METHODS...

INTRODUCTION    Graves ophthalmopathy (GO) is an autoimmune disease associated with Graves disease. Its treatment is largely dependent on the severity and activity of ocular lesions. Particular attention should be given to radioiodine (RAI) therapy. Although its use is a valuable therapeutic option for hyperthyroidism, it may be followed by worsening of GO.  OBJECTIVES    The aim of the present...