background: there has never been a single case report of any parasitic zoono-sis in ile-ife while just a case of human acanthocephalan infection in nigeria is available. methods: fifty (house–rats) rattus rattus (linnaeus, 1758) were caught in houses and raw food sellers’ stalls in a market in ile-ife. a caught rat was removed from the cage and sacrificed by cervical jerking. a rat was weighed,...

objective: the nucleus accumbens (nac) receive histaminergic neurons from tuberomammillary nuclei. there are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. the aim of the present study was to assess whether the histaminergic system of the nac is involved in anxiety-related behaviors. methods:   rats   were   anesthet...

tramadol is a synthetic analgesic of opioids which has more flexible mechanisms of action than typical opioids. since it has been reported in previous study that typical opioids like morphine can affect the bone homeostasis, it is worthwhile to examine the effects of tramadol on tooth movement. in this study we investigated effects of tramadol on orthodontic tooth movement in rats.30 male wista...

inhibition of prostaglandin (pgs) production leads to decrease in orthodontic tooth movement (otm). it is not known whether inhibition of cyclooxygenase-1 (cox-1) or cyclooxygenase-2 (cox-2) is the key mechanism for this effect. in this study, the effect of celecoxib, a highly-selective cox-2 inhibitor, was investigated on otm in rats.four groups of male rats (seven animals in each goup) were u...

background: mr imaging is one of the best diagnostic modalities in medicine. during an mr imaging examination, three types of field are employed to produce images. various experimental studies have been performed about the effects of each single type of field but only few studies are available on their combination to generate mr imaging. the main objective of this research work is to study the ...

in the present study, the effects of intra-hippocampal microinjections of morphine (an opioid agonist) and naloxone (an opioid antagonist) were investigated in the formalin-induced orofacial pain in rats. orofacial pain was induced by subcutaneous injection of formalin (1 %, 50 μl) in the upper lip region and the time spent of face rubbing was measured in 3-min blocks for 45 min. formalin induc...

introduction: interaction between drugs represents a major clinical concern for health care professionals and their patients. patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin  concurrently. the aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. according to t...

objectives: crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. in the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. the contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. materials and methods: a guide cann...

objective: hypercholesterolemia is the greatest risk factor for cardiovascular diseases. the present study is conducted to evaluate the lipid lowering activity of leaves and fruits of solanum macrocarpon, a vegetable, on wistar rats experimentally rendered hypercholesterolemic by triton x-100. materials and methods: the leaves and fruits were administered (p.o.) for 7 days to rats at doses of 4...

conclusions the results of the present study revealed that the aloe vera aqueous extract had various effects on morphine withdrawal syndrome in morphine-dependent female rats . results the results of the present study showed that agitation, disparity, and floppy eyelids in group e were significantly higher than those of others groups; however, these symptoms in group c were significantly lower ...