background the hippocampus is responsible for memory. a diet full of antioxidants improves brain damage and cognitive function. regard the antioxidant effects of zingiber officinalis (ginger) and its flavonoids components. objectives the aim of this study was to evaluate the effect of the extract of ginger on memory by using hippocampus tissue of the male offspring of rats. materials and method...

background: cirrhotic patients are at a greater risk of different kinds of arrhythmias. despite the well-known arrhythmogenic effects of halothane, developing countries continue to use halothane due to its low cost. this study was designed to investigate the pathophysiology of halothane untoward effects on heart rhythm moreover was aimed to explore the effect of halothane anesthesia on the thre...

to follow-up the present study, 40 mature female rats were used. the animals were divided into test,control and sham groups. the rats in the test group were laparotomized and unilateral ovariectomy was done. on the 1st and 2nd met-oestrous after operation, the tissue samples were dissected out and processed for histological study. the intact ovary in the test group underwent a significant (p

the deleterious effects of morphine sulphate addiction on the central nervous system are welldocumented. previous studies have shown that the passage of morphine from the placenta barrier caninfluence the normal development of embryos, such as those of humans, by specific mechanisms. so, forthe first time, for the purpose of investigating the effects of morphine sulphate on pregnant animals,thr...

background & aim: diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. according to the evidence of anti-diabetic extract of biarum bovei (bb), effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. e...

background & aim: onosma stenosiphon has been used as herbal medicine for healing skin cuts and rashes. however, burn healing effect of this herb has not been yet reported in pharmaceutical texts. the aim of this study was to find out the effect of herb ointment on burn healing the superficial wounds post type ii burns of back and testis region in wistar rats. experimental: a total of 24 r...

background: cadmium (cd) is an extremely toxic metal and environmental exposure to cd has been particularly problematic in the world. oral exposure to cd may result in adverse effects on a number of tissues, the immune system, and the cardiovascular system. compounds containing cd are also carcinogenic. the presence of cd in drinking water resources in the southeastern region of rafsanjan plain...

Purpose: To study the effect of simvastatin on behavioral performance in a rat model autism, and its hippocampal brain-derived BDNF-TrkB pathway.
 Methods: Twelve rats with valproic acid (VPA)-induced autism were randomly divided into group group, while six healthy served as normal control group. Rats received drug (5 mg/kg) via i.p. route, injected equivalent volume saline place simvastat...

Different parts of Icacina trichanta has been used for ethnomedicinal purposes; this study was undertaken to investigate the effects plant on CCl4- induced renal damage. Phytochemical analyses were carried out powdered sample using standard procedures. Absolute organ weight, Urea, creatinine, total protein, superoxide dismutase, catalase and malondialdehyde levels determined. Consequently, thir...

High fat diet (HFD) is one of the risk factors to obesity and diabetes. Recommended regimen for diabetes difficult abide especially HFD as it adds flavour taste buds. In this study, palm oil-enriched control (ND) were fed nicotinamide-induced type 2 rats, respectively six weeks. Additionally, metformin, a common drug used treat was given rats under treatment groups. We evaluated change urinary ...