objective: curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. the present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. materials and methods: in urethane-anesthetized rats, epileptiform activity was induced by intraco...

objective: the present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of rosa canina (r. canina) against carbon tetrachloride (ccl4)-induced hepatotoxicity in rats. methods: male wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (ccl4), r. canina 250, 500, and 750 mg/kg + ccl4 and r. canina ...

objective: crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. in the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. materials and methods: subcutaneous injection of a diluted formal...

results the mean number and size of betz cells in the stressed group decreased significantly compared to those in the control group (p < 0.05). qualitative observations revealed chromatolysis of nissl bodies, nucleus condensation, and a decrease in neural processes. the mean number of apoptotic cells in the stressed group were also significantly increased compared to that of the control group (...

conclusions the results of the present study show that administration of t. foenum-graecum corrects metabolic and inflammatory alterations associated with ovariectomy and has a potential for the management of menopause. objectives the purpose of this study was to examine the effect of t. foenum-graecum seed extract in reducing the metabolic and inflammatory alternations associated with menopaus...

background: nicotine can activate dopaminergic neurons within the ventral tegmental area (vta). however, there is no evidence about complete inhibition of vta on nicotine reinforcement. methods: in the present study, we used conditioned-place preference (cpp) method to study the effect of transient inhibition of left and/or right side of the vta by lidocaine on nicotine reward properties. male ...

background: previous studies have confirm the effects of water extract of crocus sativus on the euphoric and behavioral properties of morphine in mice. objective: in the present study, the effects of intra-accumbal administration of alcohol extract of crocus sativus stigma on the acquisition and expression of morphine-induced conditioned place preference (cpp) in male wistar rats (250-300 g) we...

background: tissue protective effect of compounds with antioxidant properties has been demonstrated. the alkaloids found in barberry root are considered as antioxidants. objective: according to barberry protective effects in different tissues, in this study, the protective effect of berberis integerrima bge. root )mebir) was evaluated against ccl4-induced testicular damages in wistar rats. mate...

conclusions the current study findings indicated that echinacea purpurea extract played an important role in the protection against den toxicity in rats. results den induced hepatotoxicity and nephrotoxicity in all the treated animals by elevated serum alt, ast, alp and bun, creatinin and total and direct bilirubin levels. ast, bun and total and direct bilirubin significantly decreased in den +...

recent studies have reported that metal sulfide nanoparticles had potential adverse effects.  in this research, lead (ii) sulfide nanoparticles have been synthesized under different reaction conditions. scanning electron microscopy and x-ray diffraction were used to characterize the particle size and morphology. distribution, accumulation and toxic effects of nanoparticles on rats as a biologic...