RNA-binding proteins (RBPs) play important roles in the post-transcriptional control of RNAs. Identifying RBP binding sites and characterizing RBP binding preferences are key steps toward understanding the basic mechanisms of the post-transcriptional gene regulation. Though numerous computational methods have been developed for modeling RBP binding preferences, discovering a complete structural...

The association between uteroferrin (UF, measured as acid phosphatase [AP] activity), retinol-binding protein (RBP), and transferrin (TF), within the intrauterine environment during the estrous cycle and pregnancy was examined. Pregnant gilts were killed on Days 7, 10, 13, 16, 19, 25, 30, 40, 50, 60, 70, 80, and 90. Cyclic gilts were killed on Days 7, 10, 13, and 16. On Days 7 through 19, each ...

Phage p2, a member of the lactococcal 936 phage species, infects Lactococcus lactis strains by binding initially to specific carbohydrate receptors using its receptor-binding protein (RBP). The structures of p2 RBP, a homotrimeric protein composed of three domains, and of its complex with a neutralizing llama VH domain (VHH5) have been determined (S. Spinelli, A. Desmyter, C. T. Verrips, H. J. ...

Two biochemical indicators are currently recommended for determining whether vitamin A deficiency (VAD) is a public health problem: serum retinol and serum retinol-binding protein (RBP). After consideration of 40 data sets and the original rationale for previously proposed cut-offs, a cut-off for serum retinol concentration was proposed at <0.70 micro mol/L (20 micro g/dL) in > or =15% of the s...

Renin-expressing cells are crucial in the control of blood pressure and fluid-electrolyte homeostasis. Notch receptors convey cell-cell signals that may regulate the renin cell phenotype. Because the common downstream effector for all Notch receptors is the transcription factor RBP-J, we used a conditional knockout approach to delete RBP-J in cells of the renin lineage. The resultant RBP-J cond...

We address the problem of I/O scheduling of read-once reference strings in a multiple-disk parallel I/O system.We present a novel online algorithm, Red-Black Prefetching (RBP), for parallel I/O scheduling. In order to perform accurate prefetching RBP uses L-block lookahead. The performance of RBP is analyzed in the standard parallel disk model with D independent disks and a shared I/O bu er of ...

Pichinde virus is an arenavirus that infects guinea pigs and serves as an animal model for human Lassa fever. An attenuated Pichinde virus variant (P2) and a virulent variant (P18) are being used to delineate pathogenic mechanisms that culminate in shock. In guinea pigs, the infection has been shown to begin in peritoneal macrophages following intraperitoneal inoculation and then spreads to the...

The density and distribution of the retinal pigment epithelium membrane receptor for serum retinol-binding protein (RBP) was compared in young rats (28 days postnatal) and adult rats (7.5 months postnatal) afflicted with retinal dystrophy. Following an intravascular injection of 125I-labeled RBP (125I-RBP) complexed with prealbumin, the binding of 125I-RBP was analyzed by quantitative autoradio...