The identification of DNA copy numbers from short-read sequencing data remains a challenge for both technical and algorithmic reasons. The raw data for these analyses are measured in tens to hundreds of gigabytes per genome; transmitting, storing, and analyzing such large files is cumbersome, particularly for methods that analyze several samples simultaneously. We developed a very efficient rep...

We present climatic consequences of the Representative Concentration Pathways (RCPs) using the coupled climate model CLIMBER-3α, which contains a statisticaldynamical atmosphere and a three-dimensional ocean model. We compare those with emulations of 19 state-of-the-art atmosphere-ocean general circulation models (AOGCM) using MAGICC6. The RCPs are designed as standard scenarios for the forthco...

In this thesis, we tried to improve the initiation of Rolling Circle Amplification (RCA) on genomic DNA using an approach known as Single Primer Extension (SPE). Usually, a synthetic DNA target provides a high signal on RCA after padlock probe hybridisation due to its short 3’ end. However, unfragmented genomic DNA provides low efficiency for RCA initiation due to its long 3’ end. During SPE, t...

Abstract. A column model of the Arctic atmosphere is developed including nonlinear positive feedback responses surface albedo and water vapour to temperature. The treated as a grey gas flux longwave radiation governed by two-stream Schwarzschild equations. Water concentration determined Clausius–Clapeyron equation. Representative pathways (RCPs) are used carbon dioxide concentrations into futur...

It is vital to quantify the changes in IDF relationship due climate change for designing climate-resilient urban hydraulic structures. Such projections are also important ungauged locations possible expansion or human settlements. This work proposed a method curve construction with associated uncertainty at under scenarios, considering peninsular Malaysia as case study. The bias Global Satellit...

Abstract Increasing CO2 concentration, temperature rise, and changes in rainfall due to climate change are expected influence groundwater resources irrigated agricultural regions. A simulation study using AquaCrop MODFLOW models was undertaken assess the combined effects of increasing concentrations, temperature, on behavior a rice-wheat cropping region northwest India. Simulations were carried...

The relative contributions of conservative processes are expected to be more substantial when the fraction of methylation events achieved through maintenance-type activity is elevated through loss of one or both of the de novo enzymes. Indeed, at the Lep locus, we inferred RCP values of 8.11 for Dmnt3a KO cells, a value significantly higher than that for wildtype cells (p = 0.046, two-tailed PT...

The Weighted Anomaly of Standardized Precipitation Index (WASP-Index) was computed over Iberia for three monthly timescales (3-month, 6-month and 12-month) in 1961–2020, based on an observational gridded precipitation dataset (E-OBS), between 2021 2070, bias-corrected generated by a six-member climate model ensemble from EURO-CORDEX, under two Representative Concentration Pathways (RCPs), RCP4....

The production of soybean is gaining more attention in West Africa. In light projected changes climate, there a need to assess the potential impacts on yield productivity and variability among farmers. An evaluated GROPGRO module Decision Support System for Agro-technological Transfer (DSSAT) was used simulate under both historical (1980–2009) climate scenarios from multiple general circulation...