Introduction Reduced glutathione, most commonly called glutathione or GSH, is a relatively small molecule ubiquitous in living systems. Occurring naturally in all human cells, GSH is a water-phase orthomolecule. Its intracellular depletion ultimately results in cell death and its clinical relevance has been researched for decades. GSH is the smallest intracellular thiol (–SH) molecule. Its high...

background: over the past few years, the rapid use of high frequency electromagnetic fields like mobile phones has raised global concerns about the negative health effects of its use. adaptive response is the ability of a cell or tissue to better resist stress damage by prior exposure to a lesser amount of stress. this study aimed to assess whether radiofrequency radiation can induce adaptive r...

occupational exposure to toluene is associated with development and progression of renal failure. however, the cellular mechanisms by which these agents cause renal dysfunction and injury remain elusive. the present study investigates the effect of toluene on animal model (rat) kidney to present a broader understanding of the mechanism by which toluene causes renal injury. adult male rats recei...

In order to study the interaction of glutathione, vitamin C and vitamin E under hyperoxia (95 % oxygen) and hyperbaric oxygen (2.5 atmospheric pressure), 20 days old male Guinea pigs were fed with basal vitamin C free diet, while receiving a vitamin C supplement of either high concentration (50 mg/day) or low concentration (1 mg/day) for two weeks. Animals were than exposed to hyperoxia and hyp...

one of the major classes of ionotropic glutamate receptors is the class of n-methyl-d-aspartate receptors (nmdars). receptor activation recruits, via calcium signal transduction mechanisms which play important roles in oxidative metabolism, mitochondrial free radical production and occurrence of other mitochondrial factors which potentially contribute to excitotoxicity and neuronal death. in...

Abbreviations: ROS: Reactive oxygen species; H2O2: Hydrogen peroxide; CAT: Catalase; POD: peroxidase; APX: Ascorbic Acid Peroxidase; GR: Glutathione Reductase; AsA-GSH: Ascorbate-Glutathione; ASC: Reduced form of Ascorbate; DHA: Dehydroascorbate; MDHAR: Monodehydroascorbate Reductase; DHAR: Dehydroascorbate reductase; GSH: Reduced Glutathione; GSSG: Oxidized Glutathione; PDA: Potato Dextrose Ag...

glutathione, considered to be the master antioxidant (ao), is the most-important redox regulator that controls in therapeutic considerations for the adjunctive use of glutathione in management of periodontitis, in limiting the tissue damage associated with oxidative stress, and enhancing wound healing cannot beunderestimated, but need to be evaluated further through multi-centered randomized co...

The objective of this study was to evaluate the concentrations total (T-GSH), oxidised (GSSG) and reduced (GSH) glutathione in blood dairy cows, assess relationships phase number lactation, milk production, body condition score (BCS) selected biochemical parameters on its concentrations. We analysed 79 samples whole from Holstein cows. concentration assessed by spectrophotometric enzymatic meth...

Protection of nitrogenase against oxygen inactivation in diazotrophs involves numerous strategies. Glutathione is known to play an important role in scavenging oxyradicals in many living systems. The involvement of glutathione (reduced) (GSH), glutathione peroxidase (GPX) and glutathione reductase (GR) in the protection of nitrogenase in free living diazotrophs is reported here for the first ti...