the aim of this study was to evaluate the effect of estradiol (e2), oxytocin (ot), relaxin (relaximol) injection and prostaglandin e1 (misoprostol) suppository on the cervix dilation, time of cervical dilation persistency and pregnancy rate of zandi ewes using artificial insemination. eighty 3-4 years old and 55±2.5 kg weight ewes were used for this study. in experiment 1, the ewes were assigne...

background: misoprostol, a prostaglandin e1 analogue compared to prostaglandin e2, has the advantage of being inexpensive and stable at room temperature, with its proven efficacy and safety. however studies on the effect of ph on the efficacy of misoprostol have yielded conflicting results. thus its use in the induction of labour in patients with premature rupture of membrane requires further i...

Recently, investigators have shown the use of alternative prostaglandin PGE1 Misoprostol for cervical ripening and induction of labour.1,2 It is prostaglandin E1 analogue, which was introduced as the treatment of gastric ulcer, but later on FDA approved a new label for the use of Misoprostol during pregnancy.3 It has been used for many years for the first and second trimesters of pregnancy term...

Roughly 11% of induced abortions in the United States are performed after 14 weeks of gestation, most commonly by dilation and evacuatio (D&E). For aD&Eprocedure, the cervixmust be dilated sufficiently to allow passage of operative instruments and products of conceptionwithou injuring the uterus or cervical canal. Preoperative preparation of the cervix reduces the risk of cervical laceration an...

Cervical ripening is an essential factor for initiation of normal labour for vaginal delivery. Prior to onset of spontaneous labour the cervix undergoes a gradual process of ripening. But in certain cases it does not occur spontaneously at term and sometimes induction of labour is required. Then cervical ripening means high bishop score in essential for successful induction of labour. This comp...

Misoprostol, a prostaglandin E1 derivative, has been widely used in nonpregnant women because of its cervical ripening and uterotonic effects. A large number of studies have demonstrated its effectiveness in enhancing ease of cervical dilation. This review article describes its pharmacokinetic profile and the relationship between prostaglandins and cervical ripening and uterine contraction and ...

Roughly 11% of induced abortions in the United States are performed after 14 weeks of gestation, most commonly by dilation and evacuation (D&E). For a D&E procedure, the cervix must be dilated sufficiently to allow passage of operative instruments and products of conception without injuring the uterus or cervical canal. Preoperative preparation of the cervix reduces the risk of cervical lacerat...

Misoprostol, which is a prostaglandin E1 analogue, is effectively used in cervical priming in women both for labor induction and for gynecological procedures. Although its efficacy is well documented in reproductive age women, during postmenopausal period this efficacy is limited probably due to estrogen deficit. Our objective is to evaluate if estrogen deficit in postmenopausal women is import...