The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...

The present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (St-g-PMMA and Ast-g-PMMA) of starch and acetylated starch. Drug excipient compatibility was spectroscopically analyzed via FT-IR, which confirmed no interaction between drug and other excipients. Formulations were evaluated for physical characteristics like hardness,...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

the present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (st-g-pmma and ast-g-pmma) of starch and acetylated starch. drug excipient compatibility was spectroscopically analyzed via ft-ir, which confirmed no interaction between drug and other excipients. formulations were evaluated for physical characteristics like hardness,...

objective(s): this study was designed to investigate the effect of receptor for advanced glycation end products (rage), s100a12 and c-reactive protein (crp) on the release of circulating endothelial cells (cecs) from human coronary artery endothelial cells (hcaecs). materials and methods: hcaecs were cultured in increasing concentration of crp (0, 12.5, 25, 50μg/ml) or s100a12 protein (0, 4, 10...

preparation and characterization of thermoresponsive in-situ forming poloxamer hydrogel for controlled release of nile red-loaded solid lipid nanoparticles. nanoparticles (nps) are cleared rapidly from systemic circulation and do not provide sustained action in most cases. to solve this problem, this investigation introduces an erodible in-situ forming gel system as potential vehicles for prolo...

the purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. matrix system was the earliest oral extended release platform for medicinal use. matrix tablets are most commonly used methods to modulate the release profile of drugs. they are much desirable and preferred for such therapy because they offer be...

ketorolac tromethamine (kt) containing microemulsion-based gels (mbgs) have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant (soybean lecithin; epikuron 200) and oil (isopropyl myristate; ipm) and the effect of formulation variables on the release profile of the drug from mbgs through intact guinea pig skin and various artificial membr...

the aim of this investigation was to design and develop nanoemulsions (nes) as novel ophthalmic delivery systems for brinzolamide (bzd). phase behavior of quaternary systems composed of triacetin and capryoltm 90 (selected oils, screened through the solubility studies), various surfactants (namely, cremophor rh 40, brij 35, labrasol and tyloxapol), transcutol p (as co-surfactant) and water a...