objective(s) the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. materials and methods microspheres were prepared by water-in-oil-in-oil (w/o1/o2) emulsion-solvent diffusion (esd). a mixed solvent system consisting of acetonitrile and dichloromethane ...

the present work focuses on preparation and characterization of erythromycin loaded gelatin nanoparticles through nanoprecipitation method. the procedure consists of the increase of the aqueous gelatin solution to the non-solvent phase containing lutherol f127. three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. the mor...

objective(s): in this work, electrospun nanofibers were explored as drug delivery vehicles using tetracycline as a model drug.  nanocomposite fibers including chitosan (cs)/poly (ethylene oxide) (peo) and antibiotic were successfully prepared using electrospinning. cs blended with peo considering a weight ratio of (90/10), and then, nanofibrous samples were successfully electrospun from their a...

a hydrophilic macromolecular network is prepared by performing graft copolymerization of poly (sodium acrylate) chains onto salep and silica gel. the reaction parameters affecting the water absorbency of the superabsorbent composite were optimized using taguchi method. ft-ir spectroscopy and thermo gravimetric analysis (tga) were used for confirming the structure of the final product and morpho...

conclusions here we review the clinical applications, advantages, and limitations of the tuberculin skin test and interferon-gamma release assays and provide an overview of the most recent systematic reviews conducted for the comparison of these tests. context it has been estimated that one-third of the world’s population are suffering from latent tuberculosis infection (ltbi). in order to cont...

A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

drug delivery via buccal mucosa by means of buccoadhesive formulations offer distinct advantages over peroral administration. recently, plant gums and exudates have been screened for their use as pharmaceutical adjuvants. the aim of this study is to evaluate matrix tablets containing plantago psyllium seed mucilage in addition to carbopol as a mucoadhesive agent, and propranolol hydrochloride a...

benzoyl peroxide (bpo) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. skin irritation is a common side effect, and it has been shown that controlled release of bpo from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. therefore, the purpose of the pres...

pegylated polypropyleneimine (ppi) dendritic scaffold was used for the delivery of an anti-leukemic drug, imatinib. the current study evolves and emerges the use pegylated ppi dendritic scaffold for the delivery of this drug. in this imatinib was synthesized and loaded with pegylated ppi dendritic scaffold. parameters such as ft-ir, nmr, sem, drug release, dsc and hemolytictoxicity are required...