objective(s): a box-behnken design was used for evaluation of eudragit coated diclofenac pellets. the purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. materials and methods: diclofenac was loaded onto the non-pareil beads using conventional coating pan. film coating of pellets was done at the same pan. the effect of pla...

In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Intraperitoneal (i.p.) injection of acute and repeated morphine at increasing doses significantly enhanced glutamate release. Only a minor tolerance developed to this dosage of morphine. AP-S (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a N...

in this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. these systems based on poly()lactide-co-glycolide)(50:50 dissolved in n-methyl-2-pyrrolidone that were evaluated in different concentrations. these systems are useful for local treatment of periodontal diseases. uv spectroscopy is used to determine drug concentration in release medium. a...

in vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (vta) in freely moving rats. intraperitoneal (i.p.) injection of acute and repeated morphine at increasing doses significantly enhanced glutamate release. only a minor tolerance developed to this dosage of morphine. ap-s (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a nmda r...

the release rate of potassium (k) from micaceous minerals plays a significant role in supplying k to plants. the objective of this study was to determine the most appropriate kinetic equation to describe potassium release from micaceous minerals as influenced by organic acids. muscovite and phlogopite were made to react with 0, 500, 2000 and 4000 ?m solutions of oxalic, citric and malic acids f...

telenomus beneficiens is a common egg parasitoid of sugarcane top borer scirpophaga excerptalis; however, in winter time the incidence of the parasitoid on top borer eggs is extremely low. t. beneficiens adults were released at various time durations into sugarcane plots to evaluate the parasitic potentiality of the parasitoid against sugarcane top-borer. the egg parasitoid t. beneficiens of su...

the use of recycled bassanite, produced from gypsum wastes, in ground improvement projects is initiated recently in japan to eliminate the huge quantities of gypsum wastes. meanwhile the use of recycled bassanite has a positive effect on the environment and economy, it has many challenges. these challenges are related to the release of fluorine more than the standard limits results in contamina...

the present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. fourier transform infrared spectroscopy (ftir) and differential scannin...