Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their complexity. DSBs can trigger either error-prone repair pathways that induce random mutations at the break sites or precise homology-directed repair pathways that generate specific insertions or deletions guided by exo...

This article proposes a novel theoretical framework for examining trust-repair discourse. The model identifies two fundamental discourse strategies available to the trust-breaker when trust is at stake (i) to engage with and act upon the discourses that represent a potential source of distrust – neutralize the negative, (ii) to communicate a trustworthy discourse identity – emphasize the positi...

Ischemic colitis is a well-described complication of major vascular surgery, especially following open abdominal aortic aneurysm repair and endovascular aneurysm repair, but also with aortoiliac surgery, aortic dissection, and thoracic aneurysm repair. Following its onset, mortality remains high, highlighting the need for rapidly identifying the onset of symptoms and, perhaps more importantly, ...

For repairable items sold with free replacement warranty, the actions available to the manufacturer to rectify failures under warranty are to (1) repair the failed item or (2) replace it with a new one. A proper repair-replace strategy can reduce the expected cost of servicing the warranty. In this paper, we study repair-replace strategies for items sold with a two-dimensional free replacement ...

A multi-heuristic schedule repair model for schedule conflict resolution is presented and its application in repairing the schedules of a prefabrication plant is described in this paper. The model combines heuristic strategies with Genetic Algorithms to repair schedules with resource constraints. The GA determines the “best” sequence of resolving schedule disturbances using heuristic rules sele...

Efficient operation of multipath routing is considered as one of the important aspects in MPLS traffic engineering. Multipath routing has an advantage over the traffic routing based on single shortest path because single path routing may lead to unbalanced traffic situations and degraded QoS (Quality of Service). The adequate strategy for the order of repairing failed links can greatly influenc...

Managing inconsistency in DL-Lite knowledge bases where the assertional base is prioritized is a crucial problem in many applications. This is especially true when the assertions are provided by multiple sources having different reliability levels. This paper first reviews existing approaches for selecting preferred repairs. It then focuses on suitable strategies for handling inconsistency in D...

Enhancing myelin repair remains an important therapeutic goal in primary demyelinating diseases of the central nervous system (CNS) such as multiple sclerosis (MS). The emerging heterogeneity of pathology within MS lesions, and differential oligodendrocyte survival in particular, suggests that therapeutic strategies may need to be tailored to an individual patient's requirements. A number of th...

The brain shows limited ability to repair itself, but neurogenesis in certain areas of the adult brain suggests that neural stem cells may be used for structural brain repair. It will be necessary to understand how neurogenesis in the adult brain is regulated to develop strategies that harness neural stem cells for therapeutic use.