The cost of servicing a warranty depends, amongst other factors, on the type of repair performed under warranty. Although ‘‘all minimal repair’’ and ‘‘all replacement’’ policies are easy to implement and analyze, they are not always feasible and/or practical. Having a combination of different types of repair often leads to lower warranty servicing costs. In this article, to reduce the warranty ...

In this paper, the Non deterministic Repairable Fault Tree (NdRFT) formalism is proposed: it allows to model failure modes of complex systems as well as their repair processes. The originality of this formalism with respect to other Fault Tree extensions is that it allows to face repair strategies optimization problems: in an NdRFT model, the decision on whether to start or not a given repair a...

The concept of using gene transfer strategies for cartilage repair originates from the idea of transferring genes encoding therapeutic factors into the repair tissue, resulting in a temporarily and spatially defined delivery of therapeutic molecules to sites of cartilage damage. This review focuses on the potential benefits of using gene therapy approaches for the repair of articular cartilage ...

This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies. The review discusses the potential of cannabinoids to protect against the degradation of cartilage in inflamed arthritic joints and the influence of cannabinoids on ...

Mitral valve repair represents the optimal surgical treatment for severe degenerative mitral regurgitation. According to the current guidelines, mitral repair is indicated in the presence of symptoms and/or signs of left ventricular (LV) dysfunction. In asymptomatic patients with preserved LV function, surgery should be considered in the presence of atrial fibrillation (AF) and/or pulmonary hyp...

Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin. However, unlike the advances that have been made over more than two decades with more complex org...

We investigated the spatial genetic structure of the tiger meta-population in the Satpura-Maikal landscape of central India using population- and individual-based genetic clustering methods on multilocus genotypic data from 273 individuals. The Satpura-Maikal landscape is classified as a global-priority Tiger Conservation Landscape (TCL) due to its potential for providing sufficient habitat tha...

Density dependence, population regulation, and variability in population size are fundamental population processes, the manifestation and interrelationships of which are affected by environmental variability. However, there are surprisingly few empirical studies that distinguish the effect of environmental variability from the effects of population processes. We took advantage of a unique syste...

The web has changed the way we do things in a variety of ways. It is not uncommon to associate the term disruptive technologies to the radical changes happening on the web. This paper takes an encompassing view of developments surrounding the web with a particular emphasis on emerging trends and evolving application scenarios. We provide a broad overview of technologies, in revealing directions...