The effects of estrogen replacement therapy on prognosis in women with established coronary disease remain uncertain. The authors conducted a retrospective cohort study of 726 women (mean age, 66.2 years) who survived first myocardial infarction to hospital discharge from 1980 through 1991, while enrolled at Group Health Cooperative of Puget Sound in western Washington State. Estrogen replaceme...

OBJECTIVE To assess whether recent epidemiologic evidence supports an association between use of estrogen replacement therapy or hormone replacement therapy and risk of breast cancer. DATA SOURCES The keywords "estrogen," "estrogen replacement therapy," or "hormone replacement therapy," and "breast cancer" or "breast neoplasm," were used to search for articles published from 1975-2000 in MEDL...

The role of estrogens in the prevention of cardiovascular disease is currently of particular interest. Recently, Wenger1 reviewed various randomized clinical trials to assess the effect of hormone replacement therapy in cardiovascular disease and concluded that postmenopausal hormone therapy does not prevent clinical cardiovascular events in healthy women or women with heart disease. The questi...

OBJECTIVES To investigate the effects of 24 weeks of whole-body-vibration (WBV) training on knee-extension strength and speed of movement and on counter-movement jump performance in older women. DESIGN A randomized, controlled trial. SETTING Exercise Physiology and Biomechanics Laboratory, Leuven, Belgium. PARTICIPANTS Eighty-nine postmenopausal women, off hormone replacement therapy, age...

OBJECTIVES To compare tibolone therapy with four different estrogen replacement therapy protocols, with regard to the effects on plasma lipid profiles. METHODS The plasma lipid levels of 178 postmenopausal women in five different therapy groups were compared with each other as well as their baseline levels with 6-month intervals during 2-year follow-up. Student's t-test, paired t-test and Pea...

AIMS To investigate prescribing patterns to prevent steroid induced osteoporosis. To compare prophylactic prescribing with National Osteoporosis Society (NOS) guidelines. METHOD All patients (n=92) taking oral corticosteroids admitted to general medical wards at a district general hospital were prospectively investigated over a nine month period. RESULTS Variations from recommended manageme...

Cardiovascular disease is the leading cause of death in postmenopausal US women. The contribution of postmenopausal hormone replacement therapy to cardiovascular risk is one of the most controversial women's health topics. Strikingly discordant results, between observational and randomized clinical trials, have been reported. Remaining questions regarding time of hormone therapy initiation are ...

In estrogen replacement therapy in Turner syndrome, there is no report which recommends the timing of the start of estrogen therapy in relation to height or adult height prediction. We have established a prediction model for pubertal growth (height difference from the start of estrogen therapy until adult height) at the start of estrogen replacement therapy. Twenty-seven Turner girls without sp...