The bioequivalence of three chemically equivalent paracetamol generic Mexican products (500 mg tablets) was evaluated in 12 healthy volunteers using the American innovator product (Tylenol, McNeil, Fort Washington, PA), as the reference. Single oral doses of each product were administered at 1-week intervals using a 4 x 4 Latin square design balanced for the first residual effect. The total amo...

in recent decades, most of researchers in pharmaceutical preparations have focused increasingly on new formulations that control the site and amount of drug delivery. mucoadhesive dosage forms are available for systemic or local treatment. the mucoadhesive dosage forms are introduced in various forms such as tablets, gels, ointments, patches and polymeric films. for buccal wound and injury the ...

A mean residence time (MRT) is an important pharmacokinetic parameter. To the author's knowledge, however, a physiologically based structure of MRT (thereafter MRT structure) has not been published so far. Primarily this is because MRT structures cannot be identified by traditional pharmacokinetic methods used for the determination of MRT. Therefore, tools from the theory of linear dynamic syst...

Intercomparisons of hillslopes and catchments in different hydrogeomorphic settings are rare. Those comparison studies that have been completed have focused largely on bulk outflow and chemistry. Here, we present a new functional intercomparison of two well studied hillslopes: one in New Zealand at Maimai and one in Japan at Fudoji. Slope angle, slope length, soil depth, climate and vegetation ...

In this qualitative study, researchers examined the coming out process experienced by 20 gay, lesbian, and bisexual students in the residence halls of a major research institution. The students ranged in age from 18-26 and included 10 men and 10 women. Eighteen were White, one was Asian American, and one was Latino American. Students reported how they disclosed their sexual orientation, factors...

In pre-modern societies the residence of a newly-wedded couple is often decided by custom. While researchers have analyzed factors leading to particular post-marital residence patterns, no one has explained why a society should have a customary rule in the first place. Our theory stems from contracting problems created by the nature of pre-marriage human capital investments. We argue that a fix...

       In recent decades, most of researchers in pharmaceutical preparations have focused increasingly on new formulations that control the site and amount of drug delivery. Mucoadhesive dosage forms are available for systemic or local treatment. The mucoadhesive dosage forms are introduced in various forms such as tablets, gels, ointments, patches and polymeric films. For buccal wound and inju...