Cathepsin B is a lysosomal cysteine protease, contributing to vital cellular homeostatic processes including protein turnover, macroautophagy of damaged organelles, antigen presentation, and in the extracellular space, it takes part tissue remodeling, prohormone processing, activation. However, aberrant overexpression cathepsin its enzymatic activity associated with different pathological condi...

Introduction Stimuli-responsive gels undergo abrupt changes in volume in response to environmental changes such as pH and temperature. Stimuli-responsive gels have attracted considerable attention as smart materials in the biochemical and biomedical fields, since they can sense environmental changes and induce structural changes by themselves. The fascinating properties of such stimuli-responsi...

INTRODUCTION Frequent intravitreal injections are currently the preferred treatment method for diseases affecting the posterior segment of the eye. However, these repeated injections have been associated with pain, risk of infection, hemorrhages, retinal detachment and high treatment costs. To overcome these limitations, light-responsive in situ forming injectable implants (ISFIs) may emerge as...

The target of a controlled drug delivery system is for an improved drug treatment (outcome) through rate-/time-programmed and/or site-specific drug delivery. Environmental stimuli-responsive controlled-release systems have been developed specifically for this purpose. These environmental stimuli-responsive release systems can release specified chemicals or drugs at a particular site where an en...