Background: Dopa responsive dystonia (DRD) is a disorder characterised by childhood onset dystonia but a wide range of clinical presentations has now been described. Objective: To study a large Canadian family with presumed DRD. Methods: The clinical features of the family were collected before molecular genetic mutational analysis. Results: All nine individuals in whom a clinical diagnosis of ...

Many dynamic scheduling techniques take advantage of out-of-order instruction execution to hide memory access latency. However, as the disparity between processor and memory speeds increases, delays in the load-store queue become more of a bottleneck. One way to mitigate these delays is to allow loads and stores to execute and retire from the load-store queue (LSQ) out-oforder. Unfortunately, w...

The main function attributed to the Rev proteins of immunodeficiency viruses is the shuttling of viral RNAs containing the Rev responsive element (RRE) via the CRM-1 export pathway from the nucleus to the cytoplasm. This restricts expression of structural proteins to the late phase of the lentiviral replication cycle. Using Rev-independent gag-pol expression plasmids of HIV-1 and simian immunod...

Responsive Web Design (RWD) enables web applications to adapt to the characteristics of different devices such as screen size which is important for mobile browsing. Today, the only W3C standard to support this adaptability is CSS media queries. However, using media queries it is impossible to create applications in a modular way, because responsive elements then always depend on the global con...

The relationship between detection threshold of inspiratory resistive loads and the peaks of the respiratory-related evoked potential (RREP) is unknown. It was hypothesized that the short-latency and long-latency peaks of the RREP would only be elicited by inspiratory loads that exceeded the detection threshold. The detection threshold for inspiratory resistive loads was measured in healthy sub...