Although stents reduce the rate of vessel restenosis, in-stent restenosis is a recognized clinical problem and it appears that patients positive for allergic patch-test reactions to the stent components nickel and molybdenum have increased rates of it. A patient with angina pectoris had repeated episodes of restenosis after stent implantation and histological examination demonstrated granulatio...

Bare metal stents have a proven safety record, but limited long-term efficacy due to in-stent restenosis. First-generation drug-eluting stents successfully countered the restenosis rate, but were hampered by concerns about their long-term safety. Second generation drug-eluting stents have combined the low restenosis rate of the first generation with improved long-term safety. We review the evol...

BACKGROUND Restenosis after angioplasty is essentially due to intimal hyperplasia. Low-molecular-weight heparins (LMWHs) have experimentally been shown to have antiproliferative effects in addition to their antithrombotic properties. Their potential in reducing restenosis remains to be established. Therefore, we wanted to test the hypothesis that LMWH plus aspirin is more effective than aspirin...

To the Editor: Kastrati et al recently reported1 significantly less restenosis with lesions randomized to deployment of one stent design (ACS RX Multi-Link, [ML]) than with a related design (Multi-Link RX Duet, [DT]) from the same manufacturer (Guidant). They attributed the difference in restenosis to the difference in strut thickness. Although the two stent designs do differ significantly in s...

BACKGROUND Restenosis represents the major limiting factor for the long-term efficacy of percutaneous coronary intervention (PCI). Several genetic factors involved in the regulation of the vascular system have been described to play a role in the pathogenesis of restenosis. We investigated whether the EPHX2 K55R polymorphism, previously linked to significantly higher risk for coronary heart dis...

A retrospective, single-center study from 2017 to 2019. Of 120 patients with advanced Rutherford class 3 and 4 chronic peripheral arterial disease (PAD), activity of coagulation factor (CF) VIII significantly increased months after open prosthetic bypass grafting (40 patients). Six CF-VIII developed graft thrombosis. Activities CF-VIII, CF-IX, CF-XI endovascular intervention Four in the group t...

A retrospective review of 11 French academic institutions (University Association for Research in Vascular Surgery—AURC) from 2005 to 2017. One hundred and twenty-one transfemoral carotid artery stent (TF-CAS) procedures were performed 112 patients (31% symptomatic). The mean interval between irradiation TF-CAS was 15 years. Duplex ultrasound examination at 1, 6, 12 months, annually thereafter....

R estenosis has been called the Achilles heel of coronary stenting and is caused by a combination of factors, including neointimal proliferation, elastic recoil, reorganization of thrombus, remodeling, and inflammation. 1 Long-term follow-up (Ͼ6 years) in patients with bare metal stents (BMS) shows that tissue proliferation reaches its peak at around 6 to 12 months and then regresses. 2 This pa...

Previous reports have suggested that peripheral vascular intervention (PVI) for intermittent claudication (IC) may be associated with poor outcome, progression to chronic limb-threatening ischemia (CLTI), and a higher risk of amputation. These data often arise from large database studies, which lack granularity combine patients treated in various settings by variety providers. The aim this stud...