EGF receptor (EGFR) promotes intestinal epithelial restitution, an important early process in the reepithelialization of ulcers. During epithelial restitution, the mechanism of EGFR activation is not known. We evaluated the role of TNF-converting enzyme (TACE), a metalloprotease disintegrin that proteolytically processes plasma membrane-anchored EGFR ligand precursors into their mature active f...

We measured cardiac mechanical restitution curves, which describe the time course of recovery of ventricular contractile strength following a steady-state beat. In the first series of experiments, we studied left ventricles that beat isovolumically throughout the experiment, allowing use of dP/dtmax as a reliable index of contractile strength independent of the influence of changing ventricular...

The analysis of cardiac electrical restitution (the relationship between an action potential duration and its preceding diastolic interval) has been used to predict arrhythmia liability. However, the procedure to measure restitution is invasive and disrupts normal physiological autonomic balance. Dynamic analysis of sequential beat-to-beat ECG data was used to study restitution under normal sin...

cet article s’intéresse aux titres littéraires et aux problèmes de leur traduction.  les stratégies de traduction sont plus nombreuses que ce que l’on croit; mais l’objectif de toute traduction est la restitution du sens. or à travers cette recherche, nous avons tenté de démontrer que la restitution du sens du titre original ne suffit absolument pas. en effet, le travail sur les mots d’un titre...

Human ventricular tissue as well as several animal ventricular preparations show a biphasic shape of the action potential duration restitution curve, with a local maximum at low diastolic intervals. We study numerically how the location and properties of this nonmonotonicity affect the stability of spiral waves. We find that, depending on the slopes of the ascending and of the descending parts ...

OBJECTIVES Our aim was to study the relationship between T-wave alternans (TWA) and rate-response (restitution) of repolarization in subjects with and without ventricular systolic dysfunction. BACKGROUND T-wave alternans is a promising predictor of sudden death, yet the mechanisms linking it with human ventricular arrhythmias are unclear. From theoretic considerations, we hypothesized that ab...

Brugada syndrome is a primary electrical disorder of the heart, predisposing affected individuals to potentially lethal, ventricular tachy-arrhythmias. A number of mechanisms have been identified as being important increasing the risk of these rhythms. Wavelength (λ) restitution has been suggested to predict the onset of action potential duration (APD) alternans in mouse Scn5a hearts modelling ...

Periodic sticking motions can occur in vibro-impact systems for certain parameter ranges. When the coefficient of restitution is low (or zero), the range of periodic sticking motions can become large. In this work the dynamics of periodic sticking orbits with both zero and non-zero coefficient of restitution are considered. The dynamics of the periodic orbit is simulated as the forcing frequenc...

In the present study a Friction-Driven oscillator is investigated analytically using perturbation method and numerically with Runge–Kutta’s integration procedure. The analytical method is also used to investigate damping performance of a single-particleimpact damper on amplitude and frequency of system over a wide range of particle-to-structure mass ratios, clearance, and coefficients of restit...