Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.

To find Epstein-Barr virus (EBV) strains with genetic variations of EBV latent membrane protein 1 (EBV-LMP1) from nasopharyngeal carcinoma (NPC), the full-length DNA of LMP1 genes from 21 NPC biopsies obtained in Hunan province in southern China was amplified and sequenced. Our sequences were compared to those previously reported by the Clustal V method. Results showed that all 21 sequences dis...

HLA-C-restricted T cells have been shown to play an important role in HIV control, but their impact on protection or pathogenesis in other viral infections remains elusive. Here, we characterized the hierarchy of HLA class I-restricted hepatitis B virus (HBV) epitopes targeted by CD8 T cells in HBV-infected subjects. The frequency of CD8 T cells specific for a panel of 18 HBV epitopes (restrict...

There have been an abundance of lifting studies performed throughout the history of biomechanical analysis however, there are few studies that have looked at the biomechanics of placing a box on a target or within a restricted space. Of those studies, none have looked at the human’s ability to precisely place the box, and none have considered precise placement in restricted space. Furthermore, ...

this study assesses the air quality of two urban localities, fahaheel and al-rabia city, to assistlocal authorities to generate information supporting the planning of pollution control strategies to keeppollutants within safe limits in the long run. in terms of diurnal and seasonal variations, almost all measured pollutants exhibited two peaks: one in the morning and another in the afternoon. t...

Firstly, in this paper, we apply the Fuzzy Restricted Variation Method to achieve an analytical and approximate unsymmetrical fuzzy solution for Fully Fuzzy Quadratic Equation. In this application, after finding the real root of 1-cut of $tilde{A}tilde{X}^{2}+tilde{B}tilde{X}+tilde{C}=tilde{D}$, initial guess is always chosen with possible unknown parameters that leads to highly accurate soluti...