Non-LTR retrotransposons are an important class of mobile elements that insert into host DNA by target-primed reverse transcription (TPRT). Non-LTR retrotransposons must bind to their mRNA, recognize and cleave their target DNA, and perform TPRT at the site of DNA cleavage. As DNA binding and cleavage are such central parts of the integration reaction, a better understanding of the endonuclease...

An increasing part of the work of chemical pathology laboratories in district general hospitals is measuring drug concentrations in plasma, both for toxicological (overdose) diagnosis and for therapeutic monitoring. It is these laboratories , and not specialised toxicological units or departments of pharmacy or clinical pharmacology, that now carry out most such tests on patients. Are clinician...