A detailed characterization of the microemulsion composition is necessary to make the phosphorimetry suitable as powerful analytical methodology. Four microemulsion systems (hexane/n-butanol/SDS/water, hexane/n-pentanol/SDS/water, hexane/3-pentanol/SDS/ water, and hexane/n-hexanol/SDS/water) were studied, establishing the oil/water (O/W) microemulsion composition with best phosphorimetric chara...

Changing the formulation variables of microemulsion systems has a significant influence on the resulting transdermal enhancement effect. NMR diffusion-ordered spectroscopy (DOSY) can offer an extremely valuable tool to interpret the differences in the obtained fluxes based on variations in self-diffusions between the drug and its locus domain. From the clinical editor: Microemulsion systems are...

In the present research, the D-(+)-Glucose–confined water nanodroplets with mean size in the range of 6-11 nm were synthesized at D-(+)-Glucose different concentrations by AOT reverse micelles (RMs) method as a function of mass fraction of droplet (MFD) at the constant water-to-surfactant molar ratio ( W=40). The dynamic light scattering of the nano-sized water droplets containing the D-(+)-Glu...

the paper is focused on the formation of calcium phosphate nanoparticles (cp) in polyelectrolyte-modified microemulsions, in a microemulsion template phase consisting of cyclohexane, water, anionic surfactantant and cosurfactant, in the presence of anionic and cationic polyelectrolyte. it is shown that polyelectrolyte, can be incorporated into the individual inverse microemulsion droplets. the ...

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

in this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. the effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

This paper describes formulation considerations and in vitro evaluation of an oleic acid-based polyelectrolytic polymer-containing microemulsion drug delivery system designed for intranasal administration of a hydrophobic model drug Olanzapine. Drug-loaded microemulsions were successfully prepared by a water titration method. The microemulsion containing 4% oleic acid, 30% surfactant mixture of...

Clove bud essential oil (CEO) and its major individual phenolic constituent eugenol were formulated as nanoparticles in water-based microemulsion systems. The oil titration method was used to incorporate different amounts of the oil and eugenol in the micellar solution of Tween-20. The Antioxidant and antimicrobial activities were evaluated using the DPPH* free radical scavenging assay and the ...

A local ordered structure constructed from solid Cu(2)O nanocubes was obtained by the radiolytic reduction of Cu(NO(3))(2) in a water-in-oil (W/O) microemulsion composed of Triton X-100, n-hexanol, cyclohexane, and water in the presence of ethylene glycol (EG). However, when Triton X-100 was replaced with Brij 56 in the microemulsion, hollow Cu(2)O nanocubes were synthesized. The addition of to...