Ribosomes play a critical role in maintaining cellular proteostasis. The binding of messenger RNA (mRNA) to the ribosome regulates kinetics protein synthesis. To generate an understanding structural, mechanistic, and dynamical features mRNA recognition ribosome, we have analysed mRNA-protein interactions through structural comparison ribosomal complex presence absence mRNA. do so, compared 3-Di...

Long non-coding RNAs (lncRNAs) play a multifaceted role in transcriptional regulation, and the potential molecular regulatory mechanisms of lncRNAs lncRNA–miRNA–mRNA networks body color formation are great significance for its selective breeding. Therefore, lncRNA-miRNA-mRNA ceRNA network red- black-colored Plectropomus leopardus were identified analyzed. Sequencing analyses 167 differentially ...

Emerging therapeutic treatments based on the production of proteins by delivering mRNA have become increasingly important in recent times. While lipid nanoparticles (LNPs) are approved vehicles for small interfering RNA delivery, there still challenges to use this formulation delivery. LNPs typically a mixture cationic lipid, distearoylphosphatidylcholine (DSPC), cholesterol, and PEG-lipid. The...