نتایج جستجو برای: rhG-CSF

تعداد نتایج: 28517  

Journal: :Antimicrobial agents and chemotherapy 1999
K Terashi M Oka S Ohdo T Furukubo C Ikeda M Fukuda H Soda S Higuchi S Kohno

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is used to counter chemotherapy-induced neutropenia. Our previous study showed an inverse correlation between serum rhG-CSF levels and the number of circulating neutrophils in cancer patients (H. Takatani, H. Soda, M. Fukuda, M. Watanabe, A. Kinoshita, T. Nakamura, and M. Oka, Antimicrob. Agents Chemother. 40:988-991, 1996). The ...

2015
Chun Ling Zhao Guang Ping Zhang Zheng Zheng Xiao Zhi Kun Ma Cai Peng Lei Shi Yuan Song Ying Ying Feng Ya Chao Zhao Xiao Shan Feng

PURPOSE We investigated whether recombinant human granulocyte colony-stimulating factor (rhG-CSF) could promote the development of preinvasive and invasive breast cancer in mouse mammary tumor virus (MMTV-erbB2) mice with estrogen receptor-positive tumors. METHODS MMTV-erbB2 mice were randomly divided into three experimental groups with 20 mice in each group. MMTV-erbB2 mice were treated with...

Journal: :Blood 1989
A Ohsaka S Kitagawa S Sakamoto Y Miura N Takanashi F Takaku M Saito

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered (50 to 800 micrograms/m2) once daily as a half-hour intravenous (IV) infusion for 14 days to seven patients with malignant lymphoma. In all patients, administration of rhG-CSF not only ameliorated the decrease in absolute neutrophil count after the cytotoxic chemotherapy but also enhanced superoxide (O2-) release...

Journal: :International journal of pharmaceutics 2006
Seung Ho Choi Tae Gwan Park

A new formulation method was developed for preparing poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with recombinant human granulocyte colony-stimulating factor (rhG-CSF). Lyophilized rhG-CSF powder and PLGA polymer were directly co-dissolved in a single organic phase, and the resulting solution was dispersed into an aqueous solution. PLGA nanoparticles encapsulating rhG-CSF were...

Journal: :Cell structure and function 1992
M Ishikawa H Iijima R Satake-Ishikawa H Tsumura A Iwamatsu T Kadoya Y Shimada H Fukamachi K Kobayashi S Matsuki

Human recombinant granulocyte-colony stimulating factor (rhG-CSF) has one free cysteine at position 17 and has two disulfide bridges (Cys36-Cys42 and Cys64-Cys74). The Cys17 of rhG-CSF was substituted with Gly, Ala, Ser, Ile, Tyr, Arg, and Pro, or deleted using site-directed mutagenesis in order to improve its thermostability. With the exception of Pro17-rhG-CSF, all mutant proteins retained bi...

Journal: :Blood 1994
R G Andrews R A Briddell G H Knitter T Opie M Bronsden D Myerson F R Appelbaum I K McNiece

Recombinant human stem cell factor (rhSCF) and recombinant human granulocyte colony-stimulating factor (rhG-CSF) are synergistic in vitro in stimulating the proliferation of hematopoietic progenitor cells and their precursors. We examined the in vivo synergy of rhSCF with rhG-CSF for stimulating hematopoiesis in vivo in baboons. Administration of low-dose (LD) rhSCF (25 micrograms/kg) alone did...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Mejeong Lee Mika Aoki Takahisa Kondo Koichi Kobayashi Kenji Okumura Kimihiro Komori Toyoaki Murohara

OBJECTIVE In vivo administration of granulocyte colony-stimulating factor (G-CSF) has been shown to facilitate regeneration of cardiovascular tissues. However, G-CSF causes marked leukocytosis that potentially induces adverse cardiovascular events. Earlier studies showed that G-CSF had direct stimulatory actions on mature endothelial cells, resulting in promotion of angiogenesis. We thus examin...

Journal: :Journal of biotechnology 2005
Qiang Yun Rui E Yang Ting Chen Jingxiu Bi Guanghui Ma Zhiguo Su

A novel preparation for polyethylene glycol (PEG) derivatives and chromatographic separation procedure of the PEGylated recombinant human granulocyte colony-stimulating factor (rhG-CSF) were designed to evaluate the reproducibility and scalability at large laboratory-scale level. The new "PEG-pellet" PEGylation mode was successfully applied to control the pH fluctuation during the conjugation r...

Journal: :Blood 2004
Carmelo Carlo-Stella Massimo Di Nicola Raffaella Milani Anna Guidetti Michele Magni Marco Milanesi Paolo Longoni Paola Matteucci Franca Formelli Fernando Ravagnani Paolo Corradini Alessandro M Gianni

The activity of recombinant human growth hormone (rhGH) in enhancing CD34(+) cell mobilization elicited by chemotherapy plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) was evaluated in 16 hard-to-mobilize patients, that is, those achieving a peak of circulating CD34+ cells 10/microL or less, or a collection of CD34(+) cells equal to or less than 2 x 10(6)/kg. Patients who...

Journal: :Blood 1990
F M Uckun L Souza K G Waddick M Wick C W Song

The purpose of this study was to investigate the in vivo radioprotective effects of recombinant human granulocyte colony stimulating factor (rhG-CSF) in lethally irradiated BALB/c mice. We initially analyzed the effects of increasing doses of rhG-CSF on survival of mice receiving 700 cGy (LD100/30) single dose total body irradiation (TBI). While 1 microgram/kg to 100 micrograms/kg doses of rhG-...

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