Since its discovery in 1981, ubiquitin-activating enzyme 1 was thought to be the only E1-type enzyme responsible for ubiquitin activation. Recently, a relatively uncharacterized E1 enzyme, designated ubiquitin-like modifier activating enzyme 6, was also shown to activate ubiquitin. Ubiquitin-activating enzyme 1 and ubiquitin-like modifier activating enzyme 6 are both essential proteins, and eac...

Genetic evidence suggests that the evolution of resistance to the insecticide diazinon in Lucilia cuprina initially produced an increase in asymmetry. At that time resistant flies were presumed to be at a selective disadvantage in the absence of diazinon. Subsequent evolution in natural populations selected modifiers to ameliorate these effects. The fitness and fluctuating asymmetry levels of r...

If constantly changing genotypes are favorable in host and parasite coevolution, an indefinite escalation of mutation rates would result despite heavy mutational loads. We theoretically study this possibility by examining the mutation modifier dynamics of host and parasite that engage in genotype-specific epidemiological interaction. In the first model, we study the evolutionarily stable (ESS) ...

in this work, we report, optical properties of cd1-xsnxte quantum dots (x= 0.05, 0.10 and 0.15) synthesized in water using thioglycolic acid (tga) as a modifier agent. the optical characterization of the samples was performed through absorption (uv) and photoluminescence spectra (pl). a red shift absorption and fluorescent emission peaks was observed which can be related to the increase of nano...

We describe two experiments using French noun-noun combinations which parallel a study carried out by Gagné (2001) using English combinations. The order of the modifier and head noun are reversed in French, allowing us to investigate whether the influence of relation priming that Gagné found is due to the order of the modifier and head noun or whether it is due to their different functional rol...

Modifier genes are an integral part of the genetic landscape in both humans and experimental organisms, but have been less well explored in mammals than other systems. A growing number of modifier genes in mouse models of disease nonetheless illustrate the potential for novel findings, while new technical advances promise many more to come. Modifier genes in mouse models include induced mutatio...

polymer application for the improvement and modification of the bitumen used in roads surfaces has expanded in recent decades. the roads engineers and constructors, therefore, have used the modified bitumen in asphalts helping in this way to increase roads and pavements service life and improving the durability of the roads and asphalts. the bitumen used in asphalt mixture constitutes only a lo...

The flow properties of blood play significant roles in tissue perfusion by contributing to hydrodynamic resistance in blood vessels. These properties are influenced by pathophysiological processes, thereby increasing the clinical relevance of blood rheology information. There is well-established clinical evidence for impaired blood fluidity in humans of advanced age, including enhanced plasma a...

Some important fundamental aspects of fluid mechanics and rheology are discussed. First, we examine the basis for the continuum approximation of fluids, and the formulation of equations in the continuum description. Then, we look at stress-strain rate relationships for simple shear flows of both viscous and viscoelastic fluids. The extension of the description to complex flows, which involves t...

The rheology of disperse systems is an important processing parameter. Being able to characterize and manipulate the flow behavior of dispersions one can ensure their optimal performance. Waterborne automotive coatings, for example, should exhibit a distinct low-shear viscosity necessary to provide good leveling but to avoid sagging at the same time. Then, a strong degree of shear thinning is n...