(15)N spin relaxation data have provided a wealth of information on protein dynamics in solution. Standard R(1), R(1)(rho), and NOE experiments aimed at (15)N[(1)H] amide moieties are complemented in this work by HA(CACO)N-type experiments allowing the measurement of nitrogen R(1) and R(1)(rho) rates at deuterated (15)N[(2)D] sites. Difference rates obtained using this approach, R(1)((15)N[(1)H...

The Rho family of small GTPases are essential during early embryonic development making it difficult to study their functions in adult animals. Using inducible transgenes expressing either a constitutively active version of the single C. elegans Rho ortholog, RHO-1, or an inhibitor of endogenous Rho (C3 transferase), we demonstrate multiple defects caused by altering Rho signaling in adult C. e...

As previously proposed in Simpson and Visser [J. Cosmol. Astropart. Phys. 02 (2019) 042], Mazza et al. 04 (2021) 082], Franzin 07 036], Lobo [Phys. Rev. D 103, 084052 (2021), the ``black bounce'' spacetimes are an interesting type of globally regular modifications ordinary black holes (such as Kerr-Newman geometry its particular cases) which generically contain a spacetime singularity (usually ...

The objective of this study was to determine if mechanisms involved in vascular dysfunction in type 2 diabetes differ with sex. Vascular reactivity, expression, and activation of rhoA and rho kinase were measured in aorta from male and female nondiabetic C57BLKS/J and diabetic BKS.Cg-m(+/+) Lepr(db)/J (db/db) mice, a model of type 2 diabetes. Relaxation to acetylcholine and nitroprusside was si...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 5 627–642 www.jcb.org/cgi/doi/10.1083/jcb.201405105 JCB 627 *B.K. Tripathi and X. Qian contributed equally to this paper. Correspondence to Douglas R. Lowy: [email protected]; or Brajendra K. Tripathi: [email protected] Abbreviations used in this paper: HBEC, human bronchial epithelial cell; IB, immunoblotting; IP, immunop...

BACKGROUND This study explored the psychometric properties (internal consistency, construct validity, discriminative ability) of the Juniper Mini Asthma Quality of Life Questionnaire (Mini AQLQ-J) and the Sydney Asthma Quality of Life Questionnaire (AQLQ-S). METHODS One hundred fourty-six adults (18-45 years) with asthma requiring regular inhaled corticosteroids were recruited to a trial of w...

In this work, we systematically study the OZI-allowed two-body strong decay properties of $1P$- and $1D$-wave $\Sigma_c$ baryons within $j $-$j$ coupling scheme in framework quark pair creation model. For a comparison, also give predictions chiral Some model dependencies can be found two models. The calculations indicate that: (i) $1P$-wave $\lambda$-mode states most likely to relatively narrow...

Rho family small GTPases serve as molecular switches in the regulation of diverse cellular functions, including actin cytoskeleton remodeling, cell migration, gene transcription, and cell proliferation. Importantly, Rho overexpression is frequently seen in many carcinomas. However, published studies have almost invariably used immortal or tumorigenic cell lines to study Rho GTPase functions and...

We establish a connection between the function space BMO and theory of quasisymmetric mappings on \emph{spaces homogeneous type} $\widetilde{X} :=(X,\rho,\mu)$. The is that logarithm generalised Jacobian an $\eta$-quasisymmetric mapping $f: \widetilde{X} \rightarrow \widetilde{X}$ always in $\rm{BMO}(\widetilde{X})$. In course proving this result, we first show $\widetilde{X}$, reverse-H\"{o}ld...