In addition to lowering cholesterol, statins may alter endothelial release of the vasodilator NO and harmful superoxide free radicals. Statins also reduce cholesterol intermediates including isoprenoids. These are important for post-translational modification of substances including the GTPases Rho and Rac. By altering the membrane association of these molecules, statins affect intracellular po...

Melanoma cells can adopt two functionally distinct forms, amoeboid and mesenchymal, which facilitates their ability to invade and colonize diverse environments during the metastatic process. Using quantitative imaging of single living tumor cells invading three-dimensional collagen matrices, in tandem with unsupervised computational analysis, we found that melanoma cells can switch between amoe...

We establish a connection between the function space BMO and theory of quasisymmetric mappings on \emph{spaces homogeneous type} $\widetilde{X} :=(X,\rho,\mu)$. The is that logarithm generalised Jacobian an $\eta$-quasisymmetric mapping $f: \widetilde{X} \rightarrow \widetilde{X}$ always in $\rm{BMO}(\widetilde{X})$. In course proving this result, we first show $\widetilde{X}$, reverse-H\"{o}ld...

In cite{p}, Park introduced the quadratic $rho$-functional inequalitiesbegin{eqnarray}label{E01}&& |f(x+y)+f(x-y)-2f(x)-2f(y)| \ && qquad le  left|rholeft(2 fleft(frac{x+y}{2}right) + 2 fleft(frac{x-y}{2}right)- f(x) -  f(y)right)right|,  nonumberend{eqnarray}where $rho$ is a fixed complex number with $|rho|

The prospect of using linkage disequilibrium (LD) for fine-scale mapping in humans has attracted considerable attention, and, during the validation of a set of single-nucleotide polymorphisms (SNPs) for linkage analysis, a set of data for 4,833 SNPs in 538 clusters was produced that provides a rich picture of local attributes of LD across the genome. LD estimates may be biased depending on the ...

rho-kinase is an effector molecule of rhoa, a monomeric gtp-binding protein, and causes ca2+ sensitization through inactivation of myosin phosphatase. the major physiological functions of rho/rho-kinase cascade include contraction, proliferation and migration in cells.there are some excellent reviews about rho/rho-kinase signal pathway, most of which focus on the specific proteins of the pathwa...

A critical problem faced by a Network Intrusion Detection System (NIDS) is that of ambiguity. The NIDS cannot always determine what traffic reaches a given host nor how that host will interpret the traffic, and attackers may exploit this ambiguity to avoid detection or cause misleading alarms. We present a novel, lightweight solution, Active Mapping, which eliminates TCP/IP-based ambiguity in a...

Rho kinase mediates the effects of inflammatory permeability factors by increasing actomyosin-generated traction forces on endothelial adherens junctions, resulting in disassembly of intercellular junctions and increased vascular leakage. In vitro, this is accompanied by the Rho kinase-driven formation of prominent radial F-actin fibers, but the in vivo relevance of those F-actin fibers has bee...

The unknown state rho of a quantum system S is determined by letting it interact with an auxiliary system A, the initial state of which is known. A one-to-one mapping can thus be realized between the density matrix rho and the probabilities of the occurrence of the eigenvalues of a single and factorized observable of S+A, so that rho can be determined by repeated measurements using a single app...