bakcground: the aim of itp treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. this study was conducted with the objective of comparing the efficacy of anti-d immunoglobulin (ig) with dexamethasone in treating childhood itp. materials and methods: in this randomized prospective control trial, 20 itp patients (platelet count< 20,000/µl) younger than 16 were s...

Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and -resistant (SRNS) variants. SRNS causes end-stage kidney disease, which cannot be cured. While the disease mechanisms of NS are not well understood, genetic mapping studies suggest a multitude of unknown single-gene causes. We combined homozygosity mapping with whole-exome resequencing and identified an ARHGDIA mutation that c...

The ability to control the physiological and pharmacological properties of synaptic receptors is a powerful tool for studying neuronal function and may be of therapeutic utility. We designed a recombinant adenovirus to deliver either a GABA(C) receptor rho(1) subunit or a mutant GABA(A) receptor beta(2) subunit lacking picrotoxin sensitivity [beta2(mut)] to hippocampal neurons. A green fluoresc...

The phenotype of articular chondrocytes is dependent on the cytoskeleton, specifically the actin microfilament architecture. Articular chondrocytes in monolayer culture undergo dedifferentiation and assume a fibroblastic phenotype. This process can be reversed by altering the actin cytoskeleton by treatment with cytochalasin. Whereas dedifferentiation has been studied on chondrocytes isolated f...

The renal glomerulus, the site of plasma ultrafiltration, is exposed to mechanical force in vivo arising from capillary blood pressure and fluid flow. Studies of cultured podocytes demonstrate that they respond to stretch by altering the structure of the actin cytoskeleton, but the mechanisms by which physical force triggers this architectural change and the signaling pathways that lead to gene...

Villalba N, Stankevicius E, Simonsen U, Prieto D. Rho kinase is involved in Ca entry of rat penile small arteries. Am J Physiol Heart Circ Physiol 294: H1923–H1932, 2008. First published January 25, 2008; doi:10.1152/ajpheart.01221.2007.—Tonic physiological activity of RhoA/Rho kinase contributes to the maintenance of penile flaccidity through its involvement in the Ca sensitization of erectile...

In the present paper, we prove some fixed point theorems by using non-decreasing mapping \(\kappa :\mathbb{R}^+\to \mathbb{R}^+\) known as altering distance function or control function, in context of \(S\)-metric space. Further, explore property \(P\) for these contractive mappings.

MOTIVATION Genes often regulate multiple traits. Identifying clusters of traits influenced by a common group of genes helps elucidate regulatory networks and can improve linkage mapping. METHODS We show that the Pearson correlation coefficient, rho L, between two LOD score profiles can, with high specificity and sensitivity, identify pairs of genes that have their transcription regulated by s...

Rho GTPases are members of the Ras superfamily and are involved in signal transduction pathways, including maintenance of cell morphology and motility, cell cycle progression, and transcription activation. We report the molecular identification in trypanosomatids (Trypanosoma cruzi) of the first member of the Rho family. The cloned Rho protein, TcRho1, shares approximately 40% homology with oth...