نتایج جستجو برای: rna based therapy
تعداد نتایج: 3687214 فیلتر نتایج به سال:
BACKGROUND The efficacy of first-generation protease inhibitor based triple-therapy against hepatitis C virus (HCV) infection is limited in HIV/HCV-coinfected patients with advanced liver fibrosis and non-response to previous peginterferon-ribavirin. These patients have a low chance of achieving a sustained virologic response (SVR) using first generation triple-therapy, with a success rate of o...
background most thalassemic patients with chronic hepatitis c virus (hcv) infection do not respond to therapy with pegylated interferon (peg-ifn) plus ribavirin (rbv) due to hepatic siderosis and rbv dose reduction caused by rbv-induced anemia. objectives in the present study, we recruited hcv genotype 1-infected thalassemic patients who had relapsed after a 48-week treatment with peg-ifn plus ...
Incorporating multiple copies of two RNAi molecules into a single nanostructure in a precisely controlled manner can provide an efficient delivery tool to regulate multiple gene pathways in the relation of mutual dependence. Here, we show a RNA nanotechnology platform for a two-in-one RNAi delivery system to contain polymeric two RNAi molecules within the same RNA nanoparticles, without the aid...
OBJECTIVE The aim of this study was to determine the suitable treatment period in patients who achieve virological response during combination therapy of peginterferon and ribavirin for chronic hepatitis C virus infection. METHODS Inclusion criteria were HCV-genotype 1b, serum HCV RNA level of > or =100 KIU/ml before treatment, and negativity of serum HCV RNA during treatment. The 366 patient...
The consequences of cancer do not just impact on the body only, but expands into the other levels of human existence, including psychological levels. Sometimes these consequences are even more painful and more destructive than physical harms, especially in children. Therefore, the use of psychotherapy for children, particularly art-based psychotherapies, is necessary. So, the main objective of ...
Background: Major thalassemia is relatively common in Iran and in looking of their need to recurrent transfusion their high risk for acquisition of HCV is revealed. These patients also suffer form liver hemosiderosis that accelerate disease excursion to cirrhosis and hepatocellular carcinoma. In this study combined therapy with interferon and amantadin has been evaluated. Methods: This prospe...
Background and Aims: Hepatitis C virus is one of the viral infections which is mainly transmitted by blood transfusion. Patients with thalassaemia frequently need blood transfusion and are in danger of HCV infection. In most cases of infection (85%) the virus evades the immune system and establishes a chronic infection that may lead to cirrhosis and liver carcinoma. Liver is the main site of HC...
Abstract The aggregation‐induced emission luminogens (AIEgens) with unique photophysical properties propel the rapid development of novel delivery systems for drugs and genes. In this review, we first presented numeral classic types based on light‐up AIEgens real‐time monitoring processes evaluation therapeutic outcomes delivered or Next, general strategies were discussed delicately structural ...
Isolation of high-quality RNA is one of the most crucial methods in molecular biology. RNA extraction from woody plants has been problematic due to the presence of rigid and woody tissues, large amounts of polysaccharides, polyphenols and other secondary metabolites. Here we present a suitable protocol for RNA isolation from a wide range of woody plants that includes eight gymnosperms and four ...
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