This peer-reviewed article was published immediately upon acceptance. It can be downloaded, printed and distributed freely for any purposes (see copyright notice below). which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT RNA interference screens have enabled the systematic analysis of many biological processes in ...

To the Editor: In his 1909 book Handcuff Secrets, Harry Houdini lifted the shroud of secrecy surrounding his performances and revealed that his mystifying capacity to escape shackles and chains was based in painstaking effort and compromise. Shaking off straightjackets for example required dislocating his shoulders, performance after performance, year after year. In the current issue of Molecul...