Abstract BACKGROUND Glioblastoma multiforme (GBM) remains a disease with debilitating survival outcomes. Cancer immunogenomics represents complementary approach to the application of genomics in developing novel immunotherapies for brain malignancies. Using cancer that we developed, called Open Reading Frame Antigen Network (O.R.A.N.), identified immunogenic neoantigens and tumor-associated ant...

The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 26...

70 words) Characterization of tissue-infiltrating T cell repertoire is critical to understanding tumorimmune interactions and autoimmune disease etiology. We present TRUST, an open source algorithm for calling the TCR transcript hypervariable CDR3 regions using unselected RNAseq data profiled from solid tissues. TRUST achieved high sensitivity in CDR3 calling even for samples with low sequencin...