Advanced management of dysmetabolic syndromes such as diabetes will benefit from a timely mechanistic insight enabling personalized medicine approaches. Herein, we present a rapid microfluidic neutrophil sorting and functional phenotyping strategy for type 2 diabetes mellitus (T2DM) patients using small blood volumes (fingerprick ~100 μL). The developed inertial microfluidics technology enables...

Ring rolling is a complicated process, in which rolling parameters influence directly the quality of ring. It is a process method with high productivity and few waste of material, widely used in transportation industry including automotive, shipbuilding, aerospace etc. During the rolling process of large-sized parts, crinkle and hollows often appear on surface, due to inconsistence of rolling m...

Leukocyte rolling is the earliest observable even in their recruitment from the circulation to inflamed tissue. This rolling is mediated largely by interaction between the selectin family of adhesion molecules and their glycosylated ligands. Although the nature of these ligands and their interaction with the selectins is not fully understood, it is accepted that expression of fucosylated sialyl...

In practical engineering, quality control of mechanical components or parts of rotational machinery is quite important. As for rolling bearings, the defects from rolling bodies, internal ring, external ring, and retainer are more focused on. Therefore, in this work, a vibration and noise test system is developed for the defect diagnosis of mechanical components above-mentioned. The key point of...

Adherence of eosinophils to vascular endothelium and their accumulation at sites of allergen challenge are hallmarks of allergic inflammation. However, the molecular mechanisms mediating eosinophil adhesion under conditions of blood flow are not well understood. The present studies were performed to identify the receptors on human eosinophils involved in initiating adhesion to activated endothe...

Micro flexible rolling aims to fabricate submillimeter thick strips with varying thickness profile, where the surface quality of products is mainly determined by initial workpiece surface roughness and subsequent surface asperity flattening process, which is affected by process parameters during rolling. This paper shows a 3D finite element model for flexible rolling of a 250 μm thick workpiece...

The continuous tandem cold rolling of metal strip is a highly nonlinear multi-variable complex process the control of which presents additional challenges over those encountered in the control of stand-alone tandem cold rolling. These challenges arise during the passage of the weld, which joins the head of the next strip to the tail of the present strip to maintain the continuity of rolling. Th...

We introduce a model for granular flow in a one-dimensional rice pile that incorporates rolling effects through a long-range rolling probability for the individual rice grains proportional to r(-rho), r being the distance traveled by a grain in a single toppling event. The exponent rho controls the average rolling distance. We have shown that the crossover from the power law to the stretched ex...

Cameras with rolling shutters are becoming more common as low-power, low-cost CMOS sensors are being used more frequently in cameras. The rolling shutter means that not all scanlines are exposed over the same time interval. The effects of a rolling shutter are noticeable when either the camera or objects in the scene are moving and can lead to systematic biases in projection estimation. We deve...

The objective of this study was to compare the rolling resistance of four common manual wheelchair tires (two pneumatic and two airless solid) and the solid tires used on a commercially available force- and moment-sensing wheel. Coast-down tests were performed with a wheelchair positioned on a two-drum dynamometer. Within each of three load conditions, tire type had a significant effect on roll...