Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydrophenyllactic acid (Figure 1), is a naturally occurring phenylpropanoid that is commonly found in species of the Boraginaceae family, the subfamily Nepetoideae of the Lamiaceae family, and in lower plants such as ferns and hornworts (Petersen and Simmonds, 2003). RA was first isolated and purified in 1958 from Rosmarinus officinalis b...

background: satureja bachtiarica bunge, an endemic species with relatively wide distribution, is traditionally used as a medicinal and spice plant in iran. objective: essential oils composition, antioxidant activities and phenolics content of wild and cultivated s. bachtiarica of yazd origin were determined in this study. methods: hydrodistilled essential oils were analyzed by gc-fid and gc-ms....

Salvianolic acids are among the main bioactive components in Salvia miltiorrhiza, and their biosynthesis has attracted widespread interest. However, previous studies on the biosynthesis of phenolic acids using next-generation sequencing platforms are limited with regard to the assembly of full-length transcripts. Based on hybrid-seq (next-generation and single molecular real-time sequencing) of...

BACKGROUND Perilla frutescens (L.) Britt. is not only an edible plant but also a traditional medicinal plant commonly used for treating common cold. It is widely cultivated in southern China. The anatomical parts of P. frutescens that are recorded as medicines in the Chinese material medica are: Perillae Caulis, Perillae Folium and Perillae Fructus, which are the dried stems, the dried leaves a...

Rosmarinic acid is commonly found in species of the Boraginaceae and the subfamily Nepetoideae (Lamiaceae). It has a number of interesting biological activities, for example, antiviral, antibacterial, anti-inflammatory, and antioxidant. The aim of the present study was to investigate the effect of the i.p. administration of caffeic and rosmarinic acid (5 and 10 mg/kg) on anti-inflammatory and n...

NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications. Alpine plants represent a valuable source for the identification of novel bioactive natural products with anti-ageing effects, especially substances that protect plants against UV r...

The extracts of Prunella vulgaris L. (Labiatae), a popular Western and Chinese herbal medicine, was shown to have anti-inflammatory properties, which might be due to partially, their rosmarinic acid content. Inhition of prostaglandine E2 (PGE2) production in lipopolysaccharide (LPS) stimulated RAW264.7 mouse macrophage cells was assessed with an enzyme immunoassay (EIA) following 8-hour treatme...