48 The mucosal gene expression in rectosigmoid mucosa (RSM) in irritable bowel syndrome 49 with diarrhea (IBS-D) is unknown. Our objectives were: first, to study mRNA expression (by 50 RT PCR of 19 genes pertaining to tight junctions, immune activation, intestinal ion transport 51 and bile acid homeostasis) in RSM in IBS-D patients (n=47) and healthy controls (n=17) and 52 study expression of a...

The purpose of this paper is to present an integrated approach for improving the quality characteristics of the injection molded part (Honda Upper Part) being manufactured at manufacturing industry (Pakistan), where the rejection rate for Honda upper part was on ramp due to sink marks defects. The proposed integrated approach embraces the concept of Design of Experiments (Taguchi Approach) and ...

blends of sorghum and soybean flours were processed in a co-rotating twin screw extruder to prepare expanded product. response surface methodology (rsm) was used to study the effect of soya level (sl), feed moisture (fm), barrel temperature (bt) and screw speed (ss) on extruder system parameters and physical properties of the extrudate. response variables were product temperature (pt), motor to...

PURPOSE The purpose of this study was to develop an algorithm based on region-based segmentation for automated calculations of human cone photoreceptor density of en face images obtained by an adaptive optics scanning laser ophthalmoscope (AOSLO). SUBJECTS AND METHODS Cone mosaics of 15 eyes of 15 healthy subjects were photographed by a custom-built AOSLO. The cone density was calculated at 0...

BACKGROUND Whole blood gene expression-based molecular diagnostic tests are becoming increasingly available. Conventional tube-based methods for obtaining RNA from whole blood can be limited by phlebotomy, volume requirements, and RNA stability during transport and storage. A dried blood spot matrix for collecting high-quality RNA, called RNA Stabilizing Matrix (RSM), was evaluated against PAXg...

Reliability theory is used to assess the sensitivity of a passive flexion and active flexion of the human lower leg Finite Element (FE) models with Total Knee Replacement (TKR) to the variability in the input parameters of the respective FE models. The sensitivity of the active flexion simulating the stair ascent of the human lower leg FE model with TKR was presented before in [1,2] whereas now...

The variation of skeletal maturity about chronological age is a sensitive indicator of population health. Age appropriate or advanced skeletal maturity is a reflection of adequate environmental and social conditions, whereas delayed maturation suggests inadequate conditions for optimal development. There remains a paucity of data, however, to indicate which specific biological and environmental...

The mucosal gene expression in rectosigmoid mucosa (RSM) in irritable bowel syndrome with diarrhea (IBS-D) is unknown. Our objectives were, first, to study mRNA expression [by RT(2) PCR of 19 genes pertaining to tight junctions, immune activation, intestinal ion transport and bile acid (BA) homeostasis] in RSM in IBS-D patients (n = 47) and healthy controls (n = 17) and study expression of a se...

Response surface methodology (RSM) is a well known technique in industrial statistics to identify optimal process and product settings. Most of the work in RSM were motivated by applications soon after World War II. Box and Wilson (1951) and Box (1957) set o® a wave of research in design, analysis and assessment of RSM. Hill and Hunter (1966) gave a detail review of work done during the 1950's ...